Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRF1 | P14222 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KCNJ1 | P48048 | 8/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL87174 | 0.81 | MAPT (0.61) | PRF1LMNAMAPTGAAKCNJ1 | |
| SCHEMBL29492902 | 0.81 | MAPT (0.61) | PRF1LMNAMAPTGAAKCNJ1 | |
| SCHEMBL29366960 | 0.70 | PRF1 (0.65) | PRF1LMNAMAPTGAAKCNJ1 | |
| SCHEMBL1641 | 0.70 | PRF1 (0.65) | PRF1LMNAMAPTGAAKCNJ1 | |
| SCHEMBL29580859 | 0.70 | ALDH1A1 (0.51) | PRF1LMNAMAPTGAAALDH1A1 | |
| SCHEMBL28895323 | 0.70 | ALDH1A1 (0.51) | PRF1LMNAMAPTGAAALDH1A1 | |
| SCHEMBL15192501 | 0.70 | MAPT (0.47) | PRF1LMNAMAPTGAAKCNJ1 | |
| SCHEMBL14177746 | 0.69 | ALDH1A1 (0.44) | PRF1LMNAMAPTGAAKCNJ1 | |
| SCHEMBL854664 | 0.68 | MAOA (0.62) | LMNAMAPTGAAMAOAMAOB | |
| SCHEMBL29440632 | 0.68 | MAOA (0.62) | LMNAMAPTGAAMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231638-A1 | PHTHALAZINONE DERIVATIVES | AstraZeneca AB (SE) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009093032-A1 | PHTHALAZINONE DERIVATIVES | ASTRAZENECA AB (SE) | 2009-07-30 | — | — | WO | disclosed |