SCHEMBL3666739

SCHEMBL3666739

COC(=O)c1cc(-n2c3ccccc3c3cc(C(C)(C)C)ccc32)nc(-n2c3ccccc3c3cc(C(C)(C)C)ccc32)c1

nearest known ligand 0.46

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
PTGER4 P35408 5/20 0.43
KIF11 P52732 1/20 0.41
SCARB1 Q8WTV0 1/20 0.40
KDM4E B2RXH2 1/20 0.39
LMNA P02545 1/20 0.39
MAPK14 Q16539 1/20 0.38
F2 P00734 1/20 0.38
PLAU P00749 1/20 0.38
ELANE P08246 1/20 0.38
CA1 P00915 1/20 0.38
CA2 P00918 1/20 0.38
MAPK8 P45983 2/20 0.38
POLB P06746 1/20 0.37
PPARG P37231 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13018678 0.94 KIF11 (0.45) KIF11KDM4ELMNAF2CA1
SCHEMBL3663983 0.89 PTGER4 (0.46) PTGER4KIF11KDM4ELMNAF2
SCHEMBL13063217 0.85 KIF11 (0.44) KIF11KDM4ELMNAF2CA1
SCHEMBL13768194 0.85 KIF11 (0.44) KIF11KDM4ELMNAF2CA1
SCHEMBL13767956 0.80 KIF11 (0.35) KIF11SCARB1LMNAF2CA1
SCHEMBL22852987 0.76 KDM4E (0.39) KIF11KDM4ELMNAPOLBPPARG
SCHEMBL19757516 0.74 CNR2 (0.37) PTGER4SCARB1LMNAPPARG
SCHEMBL20252383 0.74 POLB (0.41) PTGER4KDM4ELMNAF2PLAU
SCHEMBL24604375 0.73 KIF11 (0.44) KIF11KDM4ELMNAMAPK8PPARG
SCHEMBL986790 0.73 TSHR (0.48) KIF11KDM4ELMNAF2PLAU

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8546505-B2 Carbazole-based hole transport and/or electron blocking materials and/or host polymer materials GEORGIA TECH RESEARCH CORPORATION (US) 2013-10-01 US disclosed
US-20100331509-A1 Carbazole-based hole transport and/or electron blocking materials and/or host polymer materials GEORGIA TECH RESEARCH CORPORATION (US) 2010-12-30 US disclosed
EP-2234969-A2 CARBAZOLE-BASED HOLE TRANSPORT AND /OR ELECTRON BLOCKING MATERIALS AND /OR HOST POLYMER MATERIALS Georgia Tech Research Corporation (US) 2010-10-06 EP disclosed
WO-2009080799-A2 CARBAZOLE-BASED HOLE TRANSPORT AND /OR ELECTRON BLOCKING MATERIALS AND /OR HOST POLYMER MATERIALS GEORGIA TECH RESEARCH CORPORATION (US) 2009-07-02 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100331509-A1 Carbazole-based hole transport and/or electron blocking materials and/or host polymer materials OCIAD1, HPD, OXA1L PTGER4 1209/4885KIF11 3251/4885SCARB1 1553/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.