Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1176402 | 0.75 | GABRA1 (0.41) | GABRA1GABRB2MEN1KMT2AMAPT | |
| SCHEMBL5957034 | 0.71 | GABRA1 (0.41) | GABRA1GABRB2MEN1KMT2AMAPT | |
| SCHEMBL2437835 | 0.67 | NOS1 (0.42) | KMT2ALMNAGAA | |
| SCHEMBL22482014 | 0.67 | GABRA1 (0.47) | GABRA1GABRB2MEN1KMT2AMAPT | |
| SCHEMBL5174789 | 0.66 | GABRA1 (0.42) | GABRA1GABRB2MEN1KMT2AMAPT | |
| SCHEMBL5824091 | 0.65 | GABRA1 (0.58) | GABRA1GABRB2MEN1KMT2AMAPT | |
| SCHEMBL7829376 | 0.64 | GABRA1 (0.30) | GABRA1GABRB2 | |
| SCHEMBL29763626 | 0.64 | GABRA1 (0.56) | GABRA1GABRB2MEN1KMT2AMAPT | |
| SCHEMBL173300 | 0.64 | GABRA1 (0.56) | GABRA1GABRB2MEN1KMT2AMAPT | |
| SCHEMBL2163313 | 0.63 | MAPT (0.40) | GABRA1GABRB2MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155753-A1 | SUBSTITUTED IMIDAZOPYRIDAZINES AS PI3K LIPID KINASE INHIBITORS | Novartis Ag (CH) | 2010-02-24 | — | — | EP | claimed |
| WO-2008138834-A1 | SUBSTITUTED IMIDAZOPYRIDAZINES AS PI3K LIPID KINASE INHIBITORS | NOVARTIS AG (CH) | 2008-11-20 | — | — | WO | claimed |