Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1G | O43497 | 4/20 | 0.36 |
| ▸ | CACNA1H | O95180 | 4/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.33 |
| ▸ | FNTA | P49354 | 1/20 | 0.31 |
| ▸ | FNTB | P49356 | 1/20 | 0.31 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3811734 | 0.90 | SIGMAR1 (0.41) | CACNA1GCACNA1HSIGMAR1OPRM1OPRD1 | |
| SCHEMBL4736833 | 0.89 | CACNA1G (0.44) | CACNA1GCACNA1HSIGMAR1OPRM1OPRD1 | |
| SCHEMBL4784349 | 0.82 | CCR5 (0.40) | — | |
| SCHEMBL3811730 | 0.77 | SIGMAR1 (0.36) | CACNA1GCACNA1HSIGMAR1OPRM1OPRD1 | |
| SCHEMBL3721849 | 0.76 | CACNA1G (0.42) | CACNA1GCACNA1H | |
| Biotin SCHEMBL3666882 | 0.76 | CA12 (0.39) | F2PRSS1 | |
| SCHEMBL1832947 | 0.74 | CACNA1G (0.38) | CACNA1GCACNA1HOPRM1 | |
| SCHEMBL4675598 | 0.74 | CYP3A4 (0.40) | CACNA1GCACNA1HOPRM1OPRL1 | |
| SCHEMBL4804462 | 0.73 | CACNA1G (0.43) | CACNA1GCACNA1HOPRM1OPRD1OPRK1 | |
| SCHEMBL3666586 | 0.73 | CCR5 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155676-A2 | COMPOUNDS WITH ANTIPARASITIC ACTIVITY, APPLICATIONS THEREOF TO THE TREATMENT OF INFECTIOUS DISEASES CAUSED BY APICOMPLEXANS | Commissariat à l'Energie Atomique (FR) | 2010-02-24 | — | — | EP | claimed |
| WO-2008146172-A2 | COMPOUNDS WITH ANTIPARASITIC ACTIVITY, APPLICATIONS THEREOF TO THE TREATMENT OF INFECTIOUS DISEASES CAUSED BY APICOMPLEXANS | COMMISSARIAT A L'ENERGIE ATOMIQUE (FR) | 2008-12-04 | — | — | WO | claimed |