Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICMT | O60725 | 2/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.40 |
| ▸ | SCN2B | O60939 | 3/20 | 0.40 |
| ▸ | SCN1B | Q07699 | 3/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.40 |
| ▸ | SCN1A | P35498 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.39 |
| ▸ | HPGDS | O60760 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 2/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16917862 | 0.78 | ICMT (0.38) | ICMTSCN9AKDM4EALDH1A1AKR1C3 | |
| SCHEMBL2115428 | 0.78 | HTR6 (0.46) | SCN9ASCN2BSCN1BSCN5ASCN1A | |
| SCHEMBL13837715 | 0.78 | ICMT (0.36) | ICMTSCN9AKDM4EALDH1A1AKR1C3 | |
| SCHEMBL3720565 | 0.77 | AR (0.41) | ICMTAR | |
| SCHEMBL8530590 | 0.76 | TFPI2 (0.49) | KDM4EALDH1A1HTR6MAPT | |
| SCHEMBL12479971 | 0.76 | AKR1C3 (0.65) | ICMTAKR1C3AKR1C2HTR6PTGDR2 | |
| SCHEMBL12480731 | 0.76 | L3MBTL1 (0.49) | ICMTALDH1A1AKR1C3AKR1C2HPGD | |
| SCHEMBL3222225 | 0.75 | KDM4E (0.42) | ICMTSCN9ASCN2BSCN1BSCN5A | |
| Hydrochloric Acid SCHEMBL3221823 | 0.74 | KDM4E (0.41) | ICMTSCN9ASCN2BSCN1BSCN5A | |
| SCHEMBL13967309 | 0.73 | ICMT (0.37) | ICMTSCN9AKDM4EALDH1A1AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102316868-A | METHOD FOR TREATING MACULAR DEGENERATION | SANOFI AVENTIS | 2012-01-11 | — | — | CN | claimed |
| CN-102316868-A | METHOD FOR TREATING MACULAR DEGENERATION | SANOFI AVENTIS | 2012-01-11 | — | — | CN | disclosed |
| EP-2142516-A1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | Sanofi-Aventis (FR) | 2010-01-13 | — | — | EP | disclosed |
| WO-2008121670-A1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | SANOFI-AVENTIS (FR) | 2008-10-09 | — | — | WO | disclosed |