Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 6/20 | 0.48 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MC4R | P32245 | 1/20 | 0.34 |
| ▸ | MC5R | P33032 | 1/20 | 0.34 |
| ▸ | MC3R | P41968 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3661675 | 0.70 | PLK1 (0.52) | GPBAR1SIRT2SIRT1SIRT3SCN9A | |
| SCHEMBL3667416 | 0.66 | SIRT2 (0.36) | GPBAR1SIRT2SIRT1SIRT3HPGD | |
| SCHEMBL4329249 | 0.65 | HPGD (0.52) | SIRT3HPGDTSHRRAB9ACNR2 | |
| SCHEMBL3667426 | 0.65 | SIRT2 (0.37) | SIRT2SIRT1SIRT3MEN1RAB9A | |
| SCHEMBL3667423 | 0.64 | SIRT2 (0.36) | SIRT2SIRT1SIRT3HPGDMEN1 | |
| SCHEMBL9853600 | 0.62 | PIN1 (0.56) | GPBAR1HPGDMEN1KMT2AL3MBTL1 | |
| SCHEMBL9853590 | 0.62 | CYP3A4 (0.46) | GPBAR1SIRT2SIRT1SIRT3HPGD | |
| SCHEMBL3455753 | 0.61 | HPGD (0.54) | SLC6A2SLC6A4KCNH2HPGDTSHR | |
| SCHEMBL3456312 | 0.61 | SLC6A2 (0.70) | SLC6A2SLC6A4KCNH2HPGDTSHR | |
| SCHEMBL9540114 | 0.61 | L3MBTL1 (0.61) | HPGDTSHRMEN1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2152671-A1 | BICYCLIC ARYL AND HETEROARYL COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS | Prosidion Limited (GB) | 2010-02-17 | — | — | EP | disclosed |
| WO-2008142454-A1 | BICYCLIC ARYL AND HETEROARYL COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS | PROSIDION LIMITED (GB) | 2008-11-27 | — | — | WO | disclosed |