Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | PREP | P48147 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MC4R | P32245 | 1/20 | 0.34 |
| ▸ | MC5R | P33032 | 1/20 | 0.34 |
| ▸ | MC3R | P41968 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.34 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | OGG1 | O15527 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3667416 | 0.85 | SIRT2 (0.36) | SIRT2SIRT1SIRT3MEN1KMT2A | |
| SCHEMBL3667426 | 0.80 | SIRT2 (0.37) | SIRT2SIRT1SIRT3MEN1KMT2A | |
| SCHEMBL3661678 | 0.76 | SIRT2 (0.47) | SIRT2SIRT1SIRT3MEN1KMT2A | |
| SCHEMBL3661674 | 0.67 | SIRT2 (0.47) | SIRT2SIRT1SIRT3MEN1KMT2A | |
| SCHEMBL3667419 | 0.64 | GPBAR1 (0.48) | SIRT2SIRT1SIRT3MEN1KMT2A | |
| SCHEMBL6981257 | 0.61 | FAAH (0.46) | ALDH1A1KDM4E | |
| Carbamic Acid SCHEMBL12079192 | 0.60 | ALDH1A1 (0.58) | SIRT2SIRT1SIRT3MEN1KMT2A | |
| SCHEMBL2784042 | 0.60 | NR4A1 (0.51) | MEN1KMT2AL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL1884690 | 0.60 | TRPA1 (0.48) | MEN1KMT2ARAB9AALDH1A1KDM4E | |
| SCHEMBL7512439 | 0.59 | PARP10 (0.48) | MEN1KMT2ARAB9AALDH1A1CARM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2152671-A1 | BICYCLIC ARYL AND HETEROARYL COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS | Prosidion Limited (GB) | 2010-02-17 | — | — | EP | disclosed |
| WO-2008142454-A1 | BICYCLIC ARYL AND HETEROARYL COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS | PROSIDION LIMITED (GB) | 2008-11-27 | — | — | WO | disclosed |