Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 16/20 | 0.34 |
| ▸ | MTOR | P42345 | 11/20 | 0.34 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.31 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3667534 | 0.88 | TXNRD1 (0.33) | — | |
| SCHEMBL3026909 | 0.80 | PIK3CA (0.32) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL3666200 | 0.75 | KCNH2 (0.34) | EGFR | |
| SCHEMBL3008602 | 0.68 | PLK1 (0.32) | — | |
| SCHEMBL3669795 | 0.64 | CSNK2A2 (0.32) | — | |
| SCHEMBL3020455 | 0.64 | TGFBR1 (0.31) | — | |
| SCHEMBL3667380 | 0.63 | MAPK8 (0.33) | PIK3CAEGFR | |
| SCHEMBL2267169 | 0.60 | NPY5R (0.44) | EGFR | |
| SCHEMBL3025404 | 0.59 | KDM4C (0.40) | — | |
| SCHEMBL6811822 | 0.58 | ALDH1A1 (0.45) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139898-A1 | COMPOUNDS | Glaxo Group Limited (GB) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008128961-A1 | COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2008-10-30 | — | — | WO | disclosed |