Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR6 | P51684 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CAPN9 | O14815 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.32 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.32 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.32 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.32 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.32 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 4/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3674251 | 0.88 | TSHR (0.38) | CCR6CYP1A2KDM4ETDP1POLB | |
| SCHEMBL3668151 | 0.82 | GPR35 (0.42) | CYP1A2KDM4ETDP1POLBCAPN9 | |
| SCHEMBL8551898 | 0.82 | MAPT (0.31) | CCR6CYP1A2MAPT | |
| SCHEMBL2903425 | 0.82 | LMNA (0.32) | CCR6CYP1A2MAPTLMNASMN1; SMN2 | |
| SCHEMBL8113307 | 0.78 | GRIN2D (0.42) | CYP1A2TDP1POLBCAPN9CASP3 | |
| SCHEMBL8123057 | 0.77 | ALDH1A1 (0.40) | CYP1A2KDM4ETDP1POLBCAPN9 | |
| SCHEMBL8123110 | 0.77 | GRIN2D (0.33) | CYP1A2CAPN9CASP3GRIN2DGRIN3B | |
| SCHEMBL8128520 | 0.77 | CAPN9 (0.31) | CYP1A2CAPN9CASP3GRIN2DGRIN3B | |
| SCHEMBL8122907 | 0.77 | TSHR (0.35) | CYP1A2TDP1CAPN9CASP3GRIN2D | |
| SCHEMBL8127087 | 0.77 | CAPN9 (0.31) | CYP1A2CAPN9CASP3GRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150248-A2 | GLUTAMATE RECEPTOR ANTAGONISTS AND METHODS OF USE | The Johns Hopkins University (US) | 2010-02-10 | — | — | EP | disclosed |
| WO-2008088820-A2 | GLUTAMATE RECEPTOR ANTAGONISTS AND METHODS OF USE | THE JOHNS HOPKINS UNIVERSITY (US) | 2008-07-24 | — | — | WO | disclosed |
| WO-1998023599-A1 | UREA AND THIOUREA DERIVATIVES OF SUBSTITUTED QUINOXALINE 2,3-DIONES AS GLUTAMATE RECEPTOR ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1998-06-04 | — | — | WO | disclosed |