Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UCHL1 | P09936 | 1/20 | 0.46 |
| ▸ | NPBWR1 | P48145 | 11/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TSPO | P30536 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | CMA1 | P23946 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL370907 | 0.84 | NPBWR1 (0.50) | UCHL1NPBWR1MCHR1ALDH1A1HTT | |
| SCHEMBL370322 | 0.80 | UCHL1 (0.66) | UCHL1NPBWR1MCHR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL15130259 | 0.79 | NPBWR1 (0.45) | UCHL1NPBWR1MCHR1ALDH1A1HTT | |
| SCHEMBL370615 | 0.77 | NPBWR1 (0.44) | UCHL1NPBWR1MCHR1ALDH1A1HTT | |
| SCHEMBL1048024 | 0.77 | NPBWR1 (0.48) | UCHL1NPBWR1MCHR1ALDH1A1HTT | |
| SCHEMBL365784 | 0.75 | CACNA1G (0.43) | ALDH1A1HTTSMN1; SMN2TSPOL3MBTL1 | |
| SCHEMBL1310046 | 0.74 | NPBWR1 (0.49) | UCHL1NPBWR1MCHR1L3MBTL1 | |
| SCHEMBL369606 | 0.74 | L3MBTL1 (0.54) | SMN1; SMN2L3MBTL1 | |
| SCHEMBL23798467 | 0.74 | UCHL1 (0.48) | UCHL1NPBWR1MCHR1ALDH1A1HTT | |
| SCHEMBL20138946 | 0.74 | NPBWR1 (0.56) | UCHL1NPBWR1MCHR1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130210809-A1 | NOVEL 2-AMINO-4-PYRAZOLYL-THIAZOLE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | BOLEA CHRISTELLE (CH) | 2013-08-15 | — | — | US | disclosed |
| EP-2595986-A2 | NOVEL 2-AMINO-4-PYRAZOLYL-THIAZOLE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Addex Pharma SA (CH) | 2013-05-29 | — | — | EP | disclosed |
| WO-2012009009-A2 | NOVEL 2-AMINO-4-PYRAZOLYL-THIAZOLE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMA S.A. (CH) | 2012-01-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130210809-A1 | NOVEL 2-AMINO-4-PYRAZOLYL-THIAZOLE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | GRM2, GRM4, GRM1 | UCHL1 4390/4885NPBWR1 582/4885MCHR1 503/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.