Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 5/20 | 0.54 |
| ▸ | RARG | P13631 | 5/20 | 0.54 |
| ▸ | RARA | P10276 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13239090 | 0.75 | RARA (0.68) | RARBRARGRARAMEN1KMT2A | |
| SCHEMBL3674507 | 0.75 | CSNK2A1 (0.54) | RARBRARGRARARAB9A | |
| SCHEMBL1479736 | 0.73 | RARA (0.57) | RARBRARGRARAMEN1KMT2A | |
| SCHEMBL1479738 | 0.73 | RARA (0.57) | RARBRARGRARAMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL5592169 | 0.72 | RARA (0.56) | RARBRARGRARAMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL5592171 | 0.72 | RARA (0.56) | RARBRARGRARAMEN1KMT2A | |
| SCHEMBL9250705 | 0.71 | ITGB3 (0.50) | RARBRARGRARAMEN1KMT2A | |
| SCHEMBL12876806 | 0.70 | RARA (0.53) | RARBRARGRARAMEN1KMT2A | |
| SCHEMBL7481036 | 0.70 | RARA (0.56) | RARBRARGRARAMEN1KMT2A | |
| Terephthalic Acid SCHEMBL11033093 | 0.69 | TSHR (0.60) | KMT2AMAPK1ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2240491-A2 | COMPOUNDS | Amura Therapeutics Limited (GB) | 2010-10-20 | — | — | EP | disclosed |
| WO-2009087379-A2 | TETRAHYDROFURO (3, 2 -B) PYRROL- 3 -ONE DERIVATIVES AS INHIBITORS OF CYSTEINE PROTEINASES | AMURA THERAPEUTICS LIMITED (GB) | 2009-07-16 | — | — | WO | disclosed |