Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.36 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3747791 | 0.81 | NPC1 (0.40) | HPGDNPC1RAB9ACA12CA9 | |
| SCHEMBL67697 | 0.80 | MEN1 (0.42) | HPGDFAAHNPC1RAB9AKMT2A | |
| SCHEMBL3511518 | 0.79 | HTR2C (0.45) | CHRNB2CHRNA4HTR7HTR2A | |
| SCHEMBL3511520 | 0.78 | FAAH (0.36) | HPGDFAAHKMT2AMEN1ALDH1A1 | |
| SCHEMBL5846680 | 0.78 | HTR7 (0.47) | FAAHALDH1A1CHRNB2CHRNA4HTR7 | |
| SCHEMBL29786265 | 0.78 | HTR7 (0.47) | FAAHALDH1A1CHRNB2CHRNA4HTR7 | |
| SCHEMBL107426 | 0.75 | HDAC1 (0.41) | HPGDFAAHKMT2AMEN1ALDH1A1 | |
| SCHEMBL19208448 | 0.74 | CFD (0.53) | NPC1RAB9AKMT2ACHRNB2CHRNA4 | |
| SCHEMBL5348846 | 0.74 | TRPV3 (0.34) | HPGDFAAHKMT2AMEN1ALDH1A1 | |
| SCHEMBL5344489 | 0.73 | FAAH (0.33) | HPGDFAAHKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2166846-B1 | INHIBITORS OF JANUS KINASES | MERCK SHARP & DOHME (US) | 2012-10-17 | — | — | EP | disclosed |
| EP-2166846-A1 | INHIBITORS OF JANUS KINASES | Merck Sharp & Dohme Corp. (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008156726-A1 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2008-12-24 | — | — | WO | disclosed |