Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.34 |
| ▸ | CFB | P00751 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.30 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.30 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.30 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.30 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3669311 | 0.86 | CFB (0.36) | TAAR1ADRA2AADRA1ACFBP2RX7 | |
| SCHEMBL3665641 | 0.86 | ADRA2A (0.33) | TAAR1ADRA2AADRA1ACFB | |
| SCHEMBL3415731 | 0.86 | TAAR1 (0.43) | TAAR1ADRA2AADRA1ACFBADRA2B | |
| SCHEMBL3668500 | 0.81 | CFB (0.35) | TAAR1ADRA2AADRA1ACFBTP53 | |
| SCHEMBL3673071 | 0.80 | ADRA2A (0.47) | TAAR1ADRA2AADRA1A | |
| SCHEMBL3667158 | 0.77 | TAAR1 (0.40) | TAAR1ADRA2AADRA1ACFBADRA2B | |
| SCHEMBL3673459 | 0.75 | P2RX7 (0.41) | CFBP2RX7 | |
| SCHEMBL3672714 | 0.75 | IDH1 (0.32) | — | |
| SCHEMBL3670063 | 0.75 | TAAR1 (0.36) | TAAR1ADRA2AADRA1ACFBADRA2B | |
| SCHEMBL3433522 | 0.74 | CFB (0.41) | TAAR1ADRA2AADRA1ACFBTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2242753-A1 | OXAZOLIDINE AND THIAZOLIDINE SELECTIVE SUBTYPE ALPHA 2 ADRENERGIC AGENTS AND METHODS FOR USE THEREOF | ALLERGAN, INC. (US) | 2010-10-27 | — | — | EP | disclosed |
| WO-2009091760-A1 | OXAZOLIDINE AND THIAZOLIDINE SELECTIVE SUBTYPE ALPHA 2 ADRENERGIC AGENTS AND METHODS FOR USE THEREOF | ALLERGAN, INC. (US) | 2009-07-23 | — | — | WO | disclosed |