Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JUN | P05412 | 1/20 | 0.68 |
| ▸ | SLC37A4 | O43826 | 6/20 | 0.60 |
| ▸ | ELANE | P08246 | 7/20 | 0.46 |
| ▸ | CTSG | P08311 | 3/20 | 0.46 |
| ▸ | ITGA2 | P17301 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 2/20 | 0.42 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23724050 | 0.84 | ALDH1A1 (0.49) | JUNSLC37A4ELANECTSGITGA2 | |
| Anthraquinone SCHEMBL3670422 | 0.84 | JUN (0.95) | JUNSLC37A4ELANECTSGALDH1A1 | |
| SCHEMBL16227089 | 0.82 | JUN (0.62) | JUNSLC37A4ELANECTSGITGA2 | |
| SCHEMBL16431884 | 0.81 | JUN (1.00) | JUNSLC37A4ELANECTSGALDH1A1 | |
| SCHEMBL16226021 | 0.78 | JUN (0.65) | JUNSLC37A4ELANECTSGITGA2 | |
| SCHEMBL16227276 | 0.72 | SLC37A4 (0.53) | JUNSLC37A4ELANEITGA2ALDH1A1 | |
| SCHEMBL9538649 | 0.71 | MEN1 (0.64) | ELANECTSGALDH1A1MAPTMEN1 | |
| SCHEMBL10950009 | 0.70 | TTR (0.49) | ELANEALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL8952406 | 0.70 | SLC37A4 (0.58) | JUNSLC37A4ELANECTSGITGA2 | |
| SCHEMBL27584372 | 0.70 | ELANE (0.57) | ELANEALDH1A1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7795302-B2 | Use of compositions for treating rosacea | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2010-09-14 | — | — | US | disclosed |
| US-20080070874-A1 | using retinoid or tetracycline as bactericide, benzoyl peroxide as metalloproteinases (MMPs) and neutrophil elastase inhibitors; antiscarring agents; reduction in procollagen biosynthesis | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2008-03-20 | — | — | US | disclosed |
| US-7268148-B2 | Compositions and methods for use against acne-induced inflammation and dermal matrix-degrading enzymes | REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2007-09-11 | — | — | US | disclosed |
| US-7078048-B2 | Method and compositions for treating rosacea | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2006-07-18 | — | — | US | disclosed |
| US-20060078582-A1 | Use of compositions for treating rosacea | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2006-04-13 | — | — | US | disclosed |
| EP-1385496-A4 | USE OF COMPOSITIONS FOR TREATING ROSACEA | UNIV MICHIGAN (US) | 2006-03-29 | — | — | EP | disclosed |
| US-20060009494-A1 | Compositions and methods for use against acne-induced inflammation and dermal matrix-degrading enzymes | VOORHEES JOHN J | 2006-01-12 | — | — | US | disclosed |
| US-20050277695-A1 | Compositions and methods for use against acne-induced inflammation and dermal matrix-degrading enzymes | VOORHEES JOHN J | 2005-12-15 | — | — | US | disclosed |
| US-20040235950-A1 | Compositions and methods for use against acne-induced inflammation and dermal matrix-degrading enzymes | REGENTS OF THE UNIVERSITY OF MICHIGAN, THE | 2004-11-25 | — | — | US | disclosed |
| EP-1385496-A2 | USE OF COMPOSITIONS FOR TREATING ROSACEA | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2004-02-04 | — | — | EP | disclosed |
| EP-1284721-A2 | COMPOSITIONS AND METHODS FOR USE AGAINST ACNE-INDUCED INFLAMMATION AND DERMAL MATRIX-DEGRADING ENZYMES | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2003-02-26 | — | — | EP | disclosed |
| US-20020183399-A1 | Method and compositions for treating rosacea | REGENTS OF THE UNIVERSITY OF MICHIGAN, THE | 2002-12-05 | — | — | US | disclosed |
| WO-2002089743-A2 | USE OF COMPOSITIONS FOR TREATING ROSACEA | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2002-11-14 | — | — | WO | disclosed |
| WO-2001089502-A2 | COMPOSITIONS AND METHODS FOR USE AGAINST ACNE-INDUCED INFLAMMATION AND DERMAL MATRIX-DEGRADING ENZYMES | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2001-11-29 | — | — | WO | disclosed |