Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29483829 | 0.80 | SMN1; SMN2 (0.56) | MAPTSMN1; SMN2ALDH1A1PKMMEN1 | |
| SCHEMBL17509 | 0.80 | SMN1; SMN2 (0.56) | MAPTSMN1; SMN2ALDH1A1PKMMEN1 | |
| Hydrochloric Acid SCHEMBL4803286 | 0.79 | SMN1; SMN2 (0.55) | MAPTSMN1; SMN2ALDH1A1PKMMEN1 | |
| SCHEMBL1207399 | 0.73 | MEN1 (0.50) | MAPTSMN1; SMN2ALDH1A1PKMMEN1 | |
| SCHEMBL14744375 | 0.69 | MAPT (0.64) | MAPTSMN1; SMN2ALDH1A1PKMMEN1 | |
| SCHEMBL6701189 | 0.68 | MEN1 (0.62) | MAPTSMN1; SMN2ALDH1A1PKMMEN1 | |
| SCHEMBL29977958 | 0.68 | SMN1; SMN2 (0.59) | MAPTSMN1; SMN2ALDH1A1PKMMEN1 | |
| SCHEMBL1256644 | 0.68 | SMN1; SMN2 (0.59) | MAPTSMN1; SMN2ALDH1A1PKMMEN1 | |
| SCHEMBL188710 | 0.68 | ALDH1A1 (0.63) | MAPTSMN1; SMN2ALDH1A1PKMMEN1 | |
| SCHEMBL31190599 | 0.67 | ALDH1A1 (0.40) | MAPTSMN1; SMN2ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2148861-A1 | ARYL PYRIDYL SULFONAMIDE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. Hoffmann-Roche AG (CH) | 2010-02-03 | — | — | EP | disclosed |
| WO-2008138594-A1 | ARYL PYRIDYL SULFONAMIDE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-11-20 | — | — | WO | disclosed |