Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NOS2 | P35228 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2287525 | 0.86 | CYP2C19 (0.47) | CYP2C19ALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL30745927 | 0.83 | CYP2C19 (0.44) | CYP2C19ALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL5132804 | 0.83 | CTSB (0.48) | CYP2C19ALDH1A1KDM4EKMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL30745936 | 0.82 | CYP2C19 (0.44) | CYP2C19ALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL3352709 | 0.81 | MAPT (0.57) | CYP2C19ALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL27775216 | 0.75 | CYP2C19 (0.50) | CYP2C19ALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL3311153 | 0.75 | KDM4E (0.46) | ALDH1A1KDM4EKMT2AMAPTTP53 | |
| SCHEMBL9249018 | 0.73 | NPC1 (0.42) | ALDH1A1KDM4EMAPTTP53NPC1 | |
| SCHEMBL27673392 | 0.73 | ALDH1A1 (0.55) | ALDH1A1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL2490913 | 0.73 | DPP4 (0.47) | ALDH1A1KDM4EMAPTTP53NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155687-A1 | DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS | Via Pharmaceuticals, Inc. (US) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008141976-A1 | DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS | VIA PHARMACEUTICALS, INC. (US) | 2008-11-27 | — | — | WO | disclosed |