Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.47 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.47 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.47 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.44 |
| ▸ | GRM1 | Q13255 | 3/20 | 0.43 |
| ▸ | NOS2 | P35228 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4233275 | 0.88 | ALDH1A1 (0.44) | ALDH1A1MAPTKDM4EATMMAPK1 | |
| SCHEMBL5954905 | 0.84 | GPR119 (0.45) | DPP4DPP8DPP9DPP7ALDH1A1 | |
| SCHEMBL3352709 | 0.81 | MAPT (0.57) | ALDH1A1MAPTKDM4EATMMAPK1 | |
| SCHEMBL26255120 | 0.78 | ALDH1A1 (0.47) | ALDH1A1MAPTKDM4EATMMAPK1 | |
| SCHEMBL3310715 | 0.75 | MALT1 (0.46) | ALDH1A1MAPTKDM4EATMMAPK1 | |
| SCHEMBL27775216 | 0.75 | CYP2C19 (0.50) | ALDH1A1MAPTKDM4ENPC1TP53 | |
| SCHEMBL12813874 | 0.74 | ALDH1A1 (0.55) | ALDH1A1MAPTKDM4EATMMAPK1 | |
| SCHEMBL13434246 | 0.73 | L3MBTL1 (0.56) | ALDH1A1MAPTKDM4EATM | |
| SCHEMBL3671270 | 0.73 | CYP2C19 (0.47) | ALDH1A1MAPTKDM4ENOS2NPC1 | |
| SCHEMBL24548016 | 0.72 | GRM1 (0.48) | DPP4DPP8DPP9DPP7ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2378878-A1 | INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE | Via Pharmaceuticals, Inc. (US) | 2011-10-26 | — | — | EP | disclosed |
| WO-2010077861-A1 | INHIBITORS OF DIACYLGLYCEROL ACLYTRANSFERASE | VIA PHARMACEUTICALS, INC (US) | 2010-07-08 | — | — | WO | disclosed |