Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.39 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.39 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.39 |
| ▸ | ITGAL | P20701 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9251140 | 0.80 | ITGB2 (0.48) | GRM1ITGB2ICAM1ITGAL | |
| SCHEMBL26255120 | 0.73 | ALDH1A1 (0.47) | NPC1TP53HPGDRAB9AALDH1A1 | |
| SCHEMBL3671270 | 0.73 | CYP2C19 (0.47) | NPC1TP53RAB9AALDH1A1NOS2 | |
| SCHEMBL2287525 | 0.73 | CYP2C19 (0.47) | NPC1TP53RAB9AALDH1A1NOS2 | |
| SCHEMBL4988396 | 0.72 | NPEPPS (0.43) | NPC1TP53HPGDRAB9AALDH1A1 | |
| SCHEMBL4984336 | 0.72 | P2RX7 (0.42) | NPC1TP53HPGDRAB9AALDH1A1 | |
| SCHEMBL28446474 | 0.72 | NPC1 (0.41) | NPC1TP53HPGDRAB9AALDH1A1 | |
| SCHEMBL5568192 | 0.72 | MEN1 (0.50) | ALDH1A1MAPTATMKDM4E | |
| SCHEMBL8269795 | 0.72 | MEN1 (0.50) | ALDH1A1MAPTATMKDM4E | |
| SCHEMBL4662072 | 0.72 | MEN1 (0.50) | ALDH1A1MAPTATMKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5405847-A | Antiallergic, antiasthmatic, anxiolytic, hypotensive agents | ASTA MEDICA AKTIENGESELLSCHAFT (DE) | 1995-04-11 | — | — | US | disclosed |
| CN-1088928-A | New 4,5-dihydro-4-oxo-pyrrolo-[1,2-α] quinazolinone | ASTA MEDICA AG (DE) | 1994-07-06 | — | — | CN | disclosed |
| EP-0584487-A2 | 4,5-Dihydro-4-oxopyrrolo (1,2-a) quinoxalines and aza-analoges and process for their preparation | ASTA Medica Aktiengesellschaft (DE) | 1994-03-02 | — | — | EP | disclosed |