Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PTGER2 | P43116 | 7/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.40 |
| ▸ | SQLE | Q14534 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3671698 | 0.90 | NAMPT (0.53) | NAMPTKMT2APTGER2PTGS1PTGS2 | |
| SCHEMBL3668838 | 0.88 | NR1H3 (0.51) | NAMPTKMT2AALDH1A1HSD17B1HSD17B2 | |
| SCHEMBL1949604 | 0.83 | PTGDR2 (0.60) | NAMPTPTGER2 | |
| SCHEMBL3670285 | 0.79 | TRPV4 (0.43) | NAMPTKMT2AHSD17B1HSD17B2TSHR | |
| SCHEMBL2773136 | 0.77 | PTGDR2 (0.56) | NAMPTPTGER2MMP1MMP9MMP13 | |
| SCHEMBL3668839 | 0.77 | NR1H3 (0.53) | NAMPTKMT2ARORCALDH1A1HSD17B1 | |
| SCHEMBL3669238 | 0.77 | ALDH1A1 (0.47) | NAMPTPTGER2PTGS1PTGS2RORC | |
| SCHEMBL3669239 | 0.74 | ALDH1A1 (0.46) | NAMPTPTGER2PTGS1PTGS2RORC | |
| SCHEMBL29642739 | 0.72 | ALDH1A1 (0.62) | NAMPTKMT2AALDH1A1NR1H3CYP11B1 | |
| SCHEMBL1946872 | 0.72 | PTGDR2 (0.67) | NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2240434-A1 | 2-PHENYL PHENOXYACETIC ACIDS USEFUL FOR TREATING INFLAMMATORY DISORDERS | Ligand Pharmaceuticals Inc. (US) | 2010-10-20 | — | — | EP | disclosed |
| WO-2009089192-A1 | 2-PHENYL PHENOXYACETIC ACIDS USEFUL FOR TREATING INFLAMMATORY DISORDERS | LIGAND PHARMACEUTICALS INC. (US) | 2009-07-16 | — | — | WO | disclosed |