Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.31 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3671905 | 0.72 | HTR1D (0.55) | HTR1AADRA2AADRA2BADRA2CSLC6A4 | |
| SCHEMBL4630003 | 0.65 | P2RX7 (0.36) | POLBHTR1D | |
| SCHEMBL3236165 | 0.63 | RAB9A (0.50) | KDM4EKMT2AL3MBTL1RAB9AGAA | |
| SCHEMBL12129099 | 0.62 | KDM4E (0.62) | KDM4EKMT2AL3MBTL1RAB9AGAA | |
| SCHEMBL27785923 | 0.61 | KDM4E (0.56) | KDM4EKMT2AL3MBTL1RAB9AGAA | |
| SCHEMBL6985548 | 0.60 | NQO1 (0.42) | KDM4EKMT2AL3MBTL1RAB9AGAA | |
| SCHEMBL1547567 | 0.60 | L3MBTL1 (0.59) | KDM4EKMT2AL3MBTL1RAB9AGAA | |
| SCHEMBL19122260 | 0.60 | KDM4E (0.42) | KDM4EKMT2AL3MBTL1RAB9AGAA | |
| SCHEMBL16572858 | 0.60 | KDM4E (0.68) | KDM4EKMT2AL3MBTL1RAB9AGAA | |
| SCHEMBL14499037 | 0.60 | SCN4A (0.61) | KDM4EKMT2AL3MBTL1RAB9AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2173720-A2 | 2-IMIDAZOLINES HAVING A GOOD AFFINITY TO THE TRACE AMINE ASSOCIATED RECEPTORS (TAARS) | F. Hoffmann-Roche AG (CH) | 2010-04-14 | — | — | EP | claimed |
| WO-2009003868-A2 | 2 -IMIDAZOLINES HAVING A GOOD AFFINITY TO THE TRACE AMINE ASSOCIATED RECEPTORS (TAARS) | F. HOFFMANN-LA ROCHE AG (CH) | 2009-01-08 | — | — | WO | claimed |