Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 5/20 | 0.36 |
| ▸ | EIF2AK1 | Q9BQI3 | 6/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4629682 | 0.76 | SIGMAR1 (0.37) | TAAR1POLB | |
| SCHEMBL4630163 | 0.69 | TAAR1 (0.32) | TAAR1 | |
| SCHEMBL9861759 | 0.68 | TAAR1 (0.43) | P2RX7TAAR1POLBPKMHTR2A | |
| SCHEMBL726569 | 0.68 | TAAR1 (0.43) | P2RX7TAAR1POLBPKMHTR2A | |
| SCHEMBL10061644 | 0.67 | P2RX7 (0.44) | P2RX7EIF2AK1TAAR1POLB | |
| SCHEMBL6358890 | 0.66 | TAAR1 (0.41) | P2RX7TAAR1POLBPKMHTR2A | |
| SCHEMBL1127909 | 0.66 | TAAR1 (0.52) | P2RX7TAAR1PKMHTR2AHTR2C | |
| SCHEMBL14127124 | 0.66 | TAAR1 (0.41) | P2RX7TAAR1POLBPKMHTR2A | |
| SCHEMBL14567074 | 0.66 | TAAR1 (0.41) | P2RX7TAAR1POLBPKMHTR2A | |
| SCHEMBL14363074 | 0.66 | IDO1 (0.43) | P2RX7TAAR1POLBPKMHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981497-A2 | USE OF SUBSTITUTED 2-IMIDAZOLE OF IMIDAZOLINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007085557-A2 | USE OF SUBSTITUTED 2-IMIDAZOLE OF IMIDAZOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-08-02 | — | — | WO | disclosed |