Known targets — ChEMBL curated mechanism
823298382338688239847Rdl1Rdl2Rdl3
The experimentally established mechanism targets of Lindane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.30 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.30 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.30 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.30 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3672217 | 0.90 | ALOX15 (0.59) | ALOX15SIGMAR1ACE2ALDH1A1PRMT3 | |
| SCHEMBL29041543 | 0.88 | ALOX15 (0.62) | ALOX15SIGMAR1ACE2ALDH1A1PRMT3 | |
| SCHEMBL14980599 | 0.79 | ALOX15 (0.50) | ALOX15SIGMAR1ACE2ALDH1A1 | |
| SCHEMBL19072067 | 0.77 | ALOX15 (0.52) | ALOX15SIGMAR1ACE2ALDH1A1 | |
| SCHEMBL9064037 | 0.76 | ALOX15 (0.44) | ALOX15SIGMAR1ALDH1A1 | |
| SCHEMBL14980601 | 0.75 | ALOX15 (0.42) | ALOX15SIGMAR1ACE2ALDH1A1 | |
| SCHEMBL8406067 | 0.74 | SIGMAR1 (0.54) | ALOX15SIGMAR1ALDH1A1 | |
| SCHEMBL17705625 | 0.74 | ALOX15 (0.43) | ALOX15SIGMAR1ACE2 | |
| SCHEMBL21214195 | 0.73 | GNAI3 (0.43) | ALOX15SIGMAR1PRMT3CARM1PRMT6 | |
| SCHEMBL19071651 | 0.71 | ALOX15 (0.42) | ALOX15SIGMAR1ACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139461-A2 | AMINO DERIVATIVES TO PREVENT NEPHROTOXICITY AND CANCER | Recepticon Aps (DK) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008113364-A2 | AMINO DERIVATIVES TO PREVENT NEPHROTOXICITY AND CANCER | RECEPTICON APS (DK) | 2008-09-25 | — | — | WO | disclosed |