Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 9/20 | 0.71 |
| ▸ | AKR1C2 | P52895 | 8/20 | 0.71 |
| ▸ | PTGS2 | P35354 | 9/20 | 0.57 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.53 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.53 |
| ▸ | ALB | P02768 | 1/20 | 0.53 |
| ▸ | ESR1 | P03372 | 1/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.53 |
| ▸ | RARB | P10826 | 1/20 | 0.53 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.53 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.53 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8834913 | 0.85 | AKR1C3 (0.53) | AKR1C3AKR1C2PTGS2ACACBFPR2 | |
| SCHEMBL59197 | 0.84 | PTGS2 (0.74) | AKR1C3AKR1C2PTGS2PTGS1CYP2C9 | |
| SCHEMBL29960739 | 0.83 | AKR1C3 (1.00) | AKR1C3AKR1C2PTGS2PTGS1SLC22A6 | |
| SCHEMBL20541007 | 0.83 | AKR1C3 (1.00) | AKR1C3AKR1C2PTGS2PTGS1SLC22A6 | |
| SCHEMBL18770086 | 0.83 | AKR1C3 (1.00) | AKR1C3AKR1C2PTGS2PTGS1SLC22A6 | |
| SCHEMBL11458833 | 0.83 | AKR1C3 (1.00) | AKR1C3AKR1C2PTGS2PTGS1SLC22A6 | |
| Ammonia Solution, Strong SCHEMBL11728310 | 0.82 | AKR1C3 (0.97) | AKR1C3AKR1C2PTGS2PTGS1SLC22A6 | |
| SCHEMBL5677024 | 0.82 | EPHX1 (0.55) | AKR1C3AKR1C2ACACBALDH1A1 | |
| SCHEMBL9493972 | 0.81 | SRC (0.54) | AKR1C3AKR1C2LMNAACACBFPR2 | |
| SCHEMBL9235111 | 0.80 | PTGS2 (0.63) | AKR1C3AKR1C2PTGS2PTGS1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7812038-B2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2010-10-12 | — | — | US | disclosed |
| US-20060276476-A1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | BIEDIGER RONALD J | 2006-12-07 | — | — | US | disclosed |
| US-6972296-B2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC. (US) | 2005-12-06 | — | — | US | disclosed |
| US-4245099-A | ANTIINFLAMMATORY, ANALGESIC, DIURETIC, ANTIPYRETIC AND HYPOTENSIVE AGENTS | ONO PHARMACEUTICAL CO., LTD. (JP) | 1981-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276476-A1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | VCAM1, ICAM1, ITGA1 | AKR1C3 809/4885AKR1C2 844/4885PTGS2 3523/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.