Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | RECQL | P46063 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CAPN9 | O14815 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8128055 | 0.87 | CYP3A4 (0.39) | MAPTMEN1KMT2ATSHRHSD17B10 | |
| SCHEMBL8115079 | 0.82 | ESPL1 (0.38) | MAPTMEN1KMT2ATSHRALDH1A1 | |
| SCHEMBL8128045 | 0.80 | POLB (0.38) | POLBHTT | |
| SCHEMBL8555748 | 0.79 | ALDH1A1 (0.40) | MAPTMEN1KMT2ATSHRALDH1A1 | |
| SCHEMBL8559761 | 0.79 | AKR1B1 (0.40) | TSHRALDH1A1CYP3A4LMNACAPN9 | |
| SCHEMBL8118374 | 0.79 | ESPL1 (0.38) | MAPTMEN1KMT2ATSHRALDH1A1 | |
| SCHEMBL3678226 | 0.78 | PTPN11 (0.44) | MAPTCYP1A2CAPN9CASP3 | |
| SCHEMBL3675781 | 0.78 | MAPT (0.48) | MAPTMEN1KMT2AALDH1A1RECQL | |
| SCHEMBL2716661 | 0.78 | TSHR (0.38) | MAPTMEN1KMT2ATSHRHSD17B10 | |
| SCHEMBL8115975 | 0.76 | ALDH3A1 (0.44) | MAPTMEN1KMT2ATSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150248-A2 | GLUTAMATE RECEPTOR ANTAGONISTS AND METHODS OF USE | The Johns Hopkins University (US) | 2010-02-10 | — | — | EP | disclosed |
| WO-2008088820-A2 | GLUTAMATE RECEPTOR ANTAGONISTS AND METHODS OF USE | THE JOHNS HOPKINS UNIVERSITY (US) | 2008-07-24 | — | — | WO | disclosed |