Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 8/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 9/20 | 0.48 |
| ▸ | PRSS2 | P07478 | 5/20 | 0.48 |
| ▸ | PRSS3 | P35030 | 5/20 | 0.48 |
| ▸ | F12 | P00748 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 2/20 | 0.41 |
| ▸ | PLG | P00747 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.41 |
| ▸ | KLK1 | P06870 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | UBE2N | P61088 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7323111 | 0.87 | F10 (0.48) | F10PRSS1PRSS2PRSS3F12 | |
| SCHEMBL5527636 | 0.80 | HDAC6 (0.38) | F10PRSS1PRSS2PRSS3CA1 | |
| SCHEMBL10177955 | 0.78 | PRSS1 (0.58) | F10PRSS1PRSS2PRSS3F12 | |
| SCHEMBL9314470 | 0.74 | LMNA (0.54) | PRSS1PRSS2PRSS3F12LMNA | |
| SCHEMBL10143513 | 0.74 | PRSS1 (0.53) | F10PRSS1PRSS2PRSS3F2 | |
| SCHEMBL12581534 | 0.74 | PLAU (0.53) | F10PRSS1PRSS2PRSS3F12 | |
| SCHEMBL7330212 | 0.73 | PRSS1 (0.49) | F10PRSS1PRSS2PRSS3PLAU | |
| Hydrochloric Acid SCHEMBL4280302 | 0.73 | LMNA (0.52) | PRSS1PRSS2PRSS3F12LMNA | |
| SCHEMBL27802082 | 0.73 | PTGS1 (0.63) | LMNAPOLBCA1CA2CA9 | |
| Hydrochloric Acid SCHEMBL9244161 | 0.72 | F2 (0.51) | F10PRSS1PRSS2PRSS3F12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100009939-A1 | CONCURRENT DRUGS | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2010-01-14 | — | — | US | claimed |
| US-7589126-B2 | 5-amidino-2-hydroxybenzenesulfonamide derivatives, pharmaceutical compositions containing the same and intermediates for their preparation | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2009-09-15 | — | — | US | claimed |
| US-7563822-B2 | Agents for the prevention or treatment of renal diseases | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2009-07-21 | — | — | US | claimed |
| EP-1331221-B1 | 5-AMIDINO-2-HYDROXYBENZENESULFONAMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATES FOR THEIR PREPARATION | KISSEI PHARMACEUTICAL (JP) | 2009-01-14 | — | — | EP | claimed |
| US-20070105825-A1 | Concurrent drugs | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2007-05-10 | — | — | US | claimed |
| US-20070105829-A1 | 5-AMIDINO-2-HYDROXYBENZENESULFONAMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATES FOR THEIR PREPARATION | Kissei Pharmaceutical Co.,Ltd. | 2007-05-10 | — | — | US | claimed |
| US-7208524-B2 | 5-amidino-2-hydroxybenzenesulfonamide derivatives, pharmaceutical compositions containing the same and intermediates for their preparation | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2007-04-24 | — | — | US | claimed |
| EP-1679067-A1 | CONCURRENT DRUGS | Kissei Pharmaceutical Co., Ltd. (JP) | 2006-07-12 | — | — | EP | claimed |
| US-20060116361-A1 | 5-Amidino-2-hydroxybenzenesulfonamide derivatives, pharmaceutical compositions containing the same and intermediates for their preparation | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2006-06-01 | — | — | US | claimed |
| US-20050107354-A1 | active ingredient a 5-amidino-2-hydroxybenzenesulfonamide derivative or a pharmaceutical acceptable salt thereof; excellent inhibitory effect on mesangial cell proliferation and decreasing effect on urine protein excretion | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2005-05-19 | — | — | US | claimed |
| US-20050014787-A1 | 5-amidino-2-hydroxybenzenesulfonamide derivatives medicinal compoistions containing the same medicinal use thereof and intermediates in the production thereof | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2005-01-20 | — | — | US | claimed |
| EP-1443041-A1 | 5-AMIDINO-2-HYDROXYBENZENESULFONAMIDE DERIVATIVES, MEDICINAL COMPOSITIONS CONTAINING THE SAME, MEDICINAL USE THEREOF AND INTERMEDIATES IN THE PRODUCTION THEREOF | Kissei Pharmaceutical Co., Ltd. (JP) | 2004-08-04 | — | — | EP | claimed |
| EP-1331221-A1 | 5-AMIDINO-2-HYDROXYBENZENESULFONAMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATES FOR THEIR PREPARATION | Kissei Pharmaceutical Co., Ltd. (JP) | 2003-07-30 | — | — | EP | claimed |
| US-20100009939-A1 | CONCURRENT DRUGS | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2010-01-14 | — | — | US | disclosed |
| US-20100009939-A1 | CONCURRENT DRUGS | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2010-01-14 | — | — | US | disclosed |
| US-7589126-B2 | 5-amidino-2-hydroxybenzenesulfonamide derivatives, pharmaceutical compositions containing the same and intermediates for their preparation | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2009-09-15 | — | — | US | disclosed |
| EP-1331221-A1 | 5-AMIDINO-2-HYDROXYBENZENESULFONAMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATES FOR THEIR PREPARATION | Kissei Pharmaceutical Co., Ltd. (JP) | 2003-07-30 | — | — | EP | disclosed |
| WO-2003040086-A1 | 5-AMIDINO-2-HYDROXYBENZENESULFONAMIDE DERIVATIVES, MEDICINAL COMPOSITIONS CONTAINING THE SAME, MEDICINAL USE THEREOF AND INTERMEDIATES IN THE PRODUCTION THEREOF | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2003-05-15 | — | — | WO | disclosed |
| JP-2003104957-A | BIPHENYLETHYLAMINE DERIVATIVE AND METHOD FOR PRODUCING THE SAME | KISSEI PHARMACEUT CO LTD | 2003-04-09 | — | — | JP | disclosed |
| WO-2002028827-A1 | 5-AMIDINO-2-HYDROXYBENZENESULFONAMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATES FOR THEIR PREPARATION | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2002-04-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107354-A1 | active ingredient a 5-amidino-2-hydroxybenzenesulfonamide derivative or a pharmaceutical acceptable salt thereof; excellent inhibitory effect on mesangial cell proliferation and decreasing effect on urine protein excretion | REN, GLS, GRB2 | F10 2371/4885PRSS1 396/4885PRSS2 77/4885 |
| US-20100009939-A1 | CONCURRENT DRUGS | CYP3A5, HPSE, SLC9A5 | F10 64/4885PRSS1 347/4885PRSS2 438/4885 |
| US-20050014787-A1 | 5-amidino-2-hydroxybenzenesulfonamide derivatives medicinal compoistions containing the same medicinal use thereof and intermediates in the production thereof | F2, HYPK, F10 | F10 3/4885PRSS1 263/4885PRSS2 159/4885 |
| US-20070105825-A1 | Concurrent drugs | CYP3A5, HPSE, SLC9A5 | F10 64/4885PRSS1 347/4885PRSS2 438/4885 |
| US-20060116361-A1 | 5-Amidino-2-hydroxybenzenesulfonamide derivatives, pharmaceutical compositions containing the same and intermediates for their preparation | F12, F2, F5 | F10 6/4885PRSS1 85/4885PRSS2 45/4885 |
| US-20070105829-A1 | 5-AMIDINO-2-HYDROXYBENZENESULFONAMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATES FOR THEIR PREPARATION | F12, F2, F5 | F10 6/4885PRSS1 85/4885PRSS2 45/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.