Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCAT2 | O15382 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.43 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3673659 | 0.80 | MKNK1 (0.38) | BCAT2NPC1RAB9ABTKALOX5AP | |
| SCHEMBL4551863 | 0.80 | SCD5 (0.44) | KDM4EALDH1A1TSHRUSP2FGFR1 | |
| SCHEMBL4551961 | 0.80 | KMT2A (0.53) | NPC1RAB9AKDM4EALDH1A1TSHR | |
| SCHEMBL798382 | 0.76 | MKNK1 (0.38) | NPC1CSNK1A1DYRK1BTYRO3GRM5 | |
| SCHEMBL3674767 | 0.75 | MAPK1 (0.48) | NPC1RAB9AALDH1A1HPGDTSHR | |
| SCHEMBL2883986 | 0.74 | SMN1; SMN2 (0.47) | NPC1RAB9AALDH1A1HPGDTSHR | |
| SCHEMBL15741721 | 0.73 | PARP1 (0.49) | BCAT2NPC1RAB9ACSNK1A1DYRK1B | |
| SCHEMBL210767 | 0.73 | BCAT2 (0.74) | BCAT2NPC1RAB9ACSNK1A1DYRK1B | |
| SCHEMBL30514077 | 0.73 | BCAT2 (0.74) | BCAT2NPC1RAB9ACSNK1A1DYRK1B | |
| SCHEMBL17184898 | 0.73 | CTNNB1 (0.56) | NPC1RAB9AALDH1A1TSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079466-A2 | SUBSTITUTED INDOLE COMPOUNDS | SmithKline Beecham Corporation (US) | 2009-07-22 | — | — | EP | claimed |
| WO-2008042571-A2 | SUBSTITUTED INDOLE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-04-10 | — | — | WO | claimed |
| EP-3325465-A2 | PESTICIDALLY ACTIVE PYRAZOLE DERIVATIVES | Syngenta Participations AG (CH) | 2018-05-30 | — | — | EP | disclosed |
| WO-2017012970-A2 | PESTICIDALLY ACTIVE PYRAZOLE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2017-01-26 | — | — | WO | disclosed |
| EP-2162136-A1 | BENZAMIDE MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME | VANDERBILT UNIVERSITY (US) | 2010-03-17 | — | — | EP | disclosed |
| EP-2079466-A2 | SUBSTITUTED INDOLE COMPOUNDS | SmithKline Beecham Corporation (US) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008151184-A1 | BENZAMIDE MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME | VANDERBILT UNIVERSITY (US) | 2008-12-11 | — | — | WO | disclosed |
| WO-2008042571-A2 | SUBSTITUTED INDOLE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-04-10 | — | — | WO | disclosed |