Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | AGER | Q15109 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | F7 | P08709 | 1/20 | 0.34 |
| ▸ | F3 | P13726 | 1/20 | 0.34 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.34 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL797912 | 0.86 | KDM4E (0.46) | KDM4EALDH1A1CYP3A4MAPTALOX15 | |
| SCHEMBL4560363 | 0.78 | MKNK1 (0.50) | MKNK1MKNK2IRAK4KDM4EALDH1A1 | |
| SCHEMBL3673661 | 0.76 | BCAT2 (0.49) | GRM5KDM4EALDH1A1MAPTTSHR | |
| SCHEMBL29771505 | 0.76 | ADORA2A (0.39) | MKNK1MKNK2IRAK4KDM4EALDH1A1 | |
| SCHEMBL798359 | 0.74 | KCNA5 (0.47) | — | |
| SCHEMBL17028059 | 0.73 | MKNK1 (0.50) | MKNK1MKNK2IRAK4GRM5KDM4E | |
| SCHEMBL2576181 | 0.72 | NPC1 (0.38) | KDM4EALDH1A1MAPTNPSR1MEN1 | |
| SCHEMBL29594571 | 0.71 | MKNK1 (0.56) | MKNK1MKNK2ALDH1A1CYP3A4F7 | |
| SCHEMBL30165669 | 0.71 | MKNK1 (0.56) | MKNK1MKNK2ALDH1A1CYP3A4F7 | |
| SCHEMBL2572631 | 0.71 | MKNK1 (0.56) | MKNK1MKNK2ALDH1A1CYP3A4F7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616465-A1 | TRIAZINE-OXADIAZOLES | Novartis AG (CH) | 2013-07-24 | — | — | EP | disclosed |
| WO-2012035023-A1 | TRIAZINE-OXADIAZOLES | NOVARTIS AG (CH) | 2012-03-22 | — | — | WO | disclosed |