Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT6A | Q92794 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 10/20 | 0.51 |
| ▸ | CA1 | P00915 | 9/20 | 0.51 |
| ▸ | CA9 | Q16790 | 9/20 | 0.51 |
| ▸ | CA12 | O43570 | 5/20 | 0.51 |
| ▸ | CA4 | P22748 | 3/20 | 0.51 |
| ▸ | CA7 | P43166 | 2/20 | 0.51 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.51 |
| ▸ | CA3 | P07451 | 1/20 | 0.51 |
| ▸ | CA6 | P23280 | 1/20 | 0.51 |
| ▸ | CA5A | P35218 | 1/20 | 0.51 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.51 |
| ▸ | CDK8 | P49336 | 1/20 | 0.47 |
| ▸ | CA13 | Q8N1Q1 | 3/20 | 0.47 |
| ▸ | IKBKB | O14920 | 1/20 | 0.46 |
| ▸ | CHUK | O15111 | 1/20 | 0.46 |
| ▸ | TTK | P33981 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 3/20 | 0.43 |
| ▸ | MAOA | P21397 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28844211 | 0.88 | CDK8 (0.46) | KAT6ACA2CA1CA9CA12 | |
| SCHEMBL28282439 | 0.80 | CA2 (0.52) | CA2CA1CA9CA12CA4 | |
| SCHEMBL1879703 | 0.75 | TSHR (0.51) | KAT6ASCN9AMAOA | |
| SCHEMBL7389467 | 0.75 | SCN9A (0.48) | KAT6ASCN9A | |
| SCHEMBL4934743 | 0.74 | KAT6A (0.45) | KAT6ASCN9A | |
| SCHEMBL14075571 | 0.74 | KAT6A (0.53) | KAT6ACA2CA1CA9CA12 | |
| SCHEMBL28032548 | 0.73 | CA2 (0.73) | CA2CA1CA9CA12CA4 | |
| Hydrochloric Acid SCHEMBL10431116 | 0.73 | KAT6A (0.52) | KAT6ACA2CA1CA9CA12 | |
| SCHEMBL5322690 | 0.73 | RAB9A (0.54) | KAT6ASCN9AMAOB | |
| SCHEMBL31287798 | 0.72 | CA2 (0.64) | KAT6ACA2CA1CA9CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2176247-A2 | DERIVATIVES OF UREA AND RELATED DIAMINES, METHODS FOR THEIR MANUFACTURE, AND USES THEREFOR | Amgen Inc. (US) | 2010-04-21 | — | — | EP | claimed |
| WO-2009009122-A2 | DERIVATIVES OF UREA AND RELATED DIAMINES, METHODS FOR THEIR MANUFACTURE, AND USES THEREFOR | AMGEN INC. (US) | 2009-01-15 | — | — | WO | claimed |