Sugi Predict

Sugi Predict / Compounds / SCHEMBL1879703

SCHEMBL1879703

SCHEMBL1879703

Nc1cccc(-c2cscn2)c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TSHR P16473 1/20 0.51
▸ RECQL P46063 1/20 0.51
▸ SCN9A Q15858 1/20 0.48
▸ RAB9A P51151 3/20 0.47
▸ NPC1 O15118 2/20 0.47
▸ ALDH1A1 P00352 5/20 0.47
▸ MEN1 O00255 4/20 0.47
▸ MAPT P10636 4/20 0.47
▸ KDM4E B2RXH2 3/20 0.47
▸ KMT2A Q03164 3/20 0.47
▸ LMNA P02545 3/20 0.47
▸ HPGD P15428 3/20 0.47
▸ MAP4K4 O95819 5/20 0.47
▸ METAP2 P50579 2/20 0.46
▸ MAOA P21397 1/20 0.45
▸ GLA P06280 1/20 0.44
▸ KAT6A Q92794 1/20 0.43
▸ NFKB1 P19838 1/20 0.42
▸ NFKB2 Q00653 1/20 0.42
▸ RELA Q04206 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18176020 0.81 EGFR (0.46) TSHRRECQLSCN9ARAB9ANPC1
SCHEMBL5322690 0.79 RAB9A (0.54) TSHRSCN9ARAB9ANPC1ALDH1A1
SCHEMBL16331516 0.78 CHEK1 (0.61) MKNK1MKNK2
SCHEMBL10151028 0.78 SCN9A (0.51) SCN9AALDH1A1MEN1KMT2AMETAP2
SCHEMBL30989356 0.78 SCN9A (0.51) SCN9AALDH1A1MEN1KMT2AMETAP2
SCHEMBL4518536 0.78 CYP19A1 (0.50) SCN9AMETAP2KAT6A
SCHEMBL30042796 0.78 CYP19A1 (0.50) SCN9AMETAP2KAT6A
SCHEMBL7389467 0.78 SCN9A (0.48) TSHRSCN9ARAB9ANPC1ALDH1A1
SCHEMBL2789456 0.78 HSD17B1 (0.58) SCN9AMETAP2KAT6A
SCHEMBL4524263 0.78 KDM4E (0.53) SCN9AALDH1A1MEN1MAPTKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109456280-A 4- phenyl thiazole -2- amine derivant containing urea structure and the preparation method and application thereof 锦州医科大学 2019-03-12 — — CN claimed
US-12358869-B2 Diarylureas as CB1 allosteric modulators RESEARCH TRIANGLE INSTITUTE 2025-07-15 — — US disclosed
EP-4532463-A1 SQUARAMIDE DERIVATIVES AS CB1 ALLOSTERIC MODULATORS Research Triangle Institute (US) 2025-04-09 — — EP disclosed
CN-119325464-A Square amide derivatives as CB1 allosteric modulators 研究三角协会 2025-01-17 — — CN disclosed
WO-2023235548-A1 SQUARAMIDE DERIVATIVES AS CB1 ALLOSTERIC MODULATORS RESEARCH TRIANGLE INSTITUTE (US) 2023-12-07 — — WO disclosed
CN-116283668-A Diaryl ureas as CB1 allosteric modulators 研究三角协会 2023-06-23 — — CN disclosed
US-20210332007-A1 DIARYLUREAS AS CB1 ALLOSTERIC MODULATORS RESEARCH TRIANGLE INSTITUTE 2021-10-28 — — US disclosed
US-11084781-B2 Diarylureas as CB1 allosteric modulators RESEARCH TRIANGLE INSTITUTE (US) 2021-08-10 — — US disclosed
US-10752624-B2 Kinase inhibitors ORIGENIS GMBH (DE) 2020-08-25 — — US disclosed
EP-3621951-A1 DIARYLUREAS AS CB1 ALLOSTERIC MODULATORS Research Triangle Institute (US) 2020-03-18 — — EP disclosed
EP-2699579-B1 PYRAZOLO[4,3-D]PYRIMIDINES USEFUL AS KINASE INHIBITORS ORIGENIS GMBH (DE) 2015-10-07 — — EP disclosed
US-20150266882-A1 PYRAZOLO[4,3-D]PYRIMIDINES AS KINASE INHIBITORS ORIGENIS GMBH (DE) 2015-09-24 — — US disclosed
US-20150259340-A1 NOVEL KINASE INHIBITORS ORIGENIS GMBH (DE) 2015-09-17 — — US disclosed
WO-2014060112-A1 PYRAZOLO[4,3-D]PYRIMIDINES AS KINASE INHIBITORS ORIGENIS GMBH (DE) 2014-04-24 — — WO disclosed
WO-2014060113-A1 NOVEL KINASE INHIBITORS ORIGENIS GMBH (DE) 2014-04-24 — — WO disclosed
US-20120329785-A1 Novel kinase inhibitors ORIGENIS GMBH (DE) 2012-12-27 — — US disclosed
US-20120329780-A1 Novel kinase inhibitors ORIGENIS GMBH (DE) 2012-12-27 — — US disclosed
EP-2498608-A1 BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS GlaxoSmithKline LLC (US) 2012-09-19 — — EP disclosed
WO-2011059610-A1 BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS GLAXOSMITHKLINE LLC (US) 2011-05-19 — — WO disclosed
CN-101035802-A Inhibitors of IAP GENENTECH INC (US) 2007-09-12 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150259340-A1 NOVEL KINASE INHIBITORS LRRK2, MYLK2, MYLK TSHR 1137/4885RECQL 2017/4885SCN9A 2599/4885
US-20150266882-A1 PYRAZOLO[4,3-D]PYRIMIDINES AS KINASE INHIBITORS LRRK2, MYLK2, MYLK TSHR 1435/4885RECQL 1038/4885SCN9A 2887/4885
US-12358869-B2 Diarylureas as CB1 allosteric modulators CNR1, CNR2, GPR18 TSHR 569/4885RECQL 4549/4885SCN9A 771/4885
US-11084781-B2 Diarylureas as CB1 allosteric modulators CNR1, CNR2, GPR18 TSHR 569/4885RECQL 4549/4885SCN9A 771/4885
US-20120329780-A1 Novel kinase inhibitors LRRK2, MYLK2, MYLK TSHR 1137/4885RECQL 2017/4885SCN9A 2599/4885
US-20120329785-A1 Novel kinase inhibitors LRRK2, MYLK2, MYLK3 TSHR 2361/4885RECQL 1461/4885SCN9A 2163/4885
US-20210332007-A1 DIARYLUREAS AS CB1 ALLOSTERIC MODULATORS CNR1, CNR2, GPR18 TSHR 569/4885RECQL 4549/4885SCN9A 771/4885
US-10752624-B2 Kinase inhibitors LRRK2, MYLK2, MYLK TSHR 1024/4885RECQL 2141/4885SCN9A 2562/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.