SCHEMBL3674362

SCHEMBL3674362

[CH2]c1ccc(C(=O)C2(O)CCCCC2)cc1C

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM2B Q8NHM5 2/20 0.34
KDM4E B2RXH2 2/20 0.34
XBP1 P17861 1/20 0.34
ALDH1A1 P00352 1/20 0.33
RXRA P19793 3/20 0.33
RXRB P28702 3/20 0.33
RXRG P48443 3/20 0.33
ESR1 P03372 2/20 0.33
KMT2A Q03164 2/20 0.33
MEN1 O00255 1/20 0.33
CYP26A1 O43174 1/20 0.33
ABCB11 O95342 1/20 0.33
PGR P06401 1/20 0.33
HTR1A P08908 1/20 0.33
ADRA2A P08913 1/20 0.33
ADORA3 P0DMS8 1/20 0.33
RARA P10276 1/20 0.33
RARB P10826 1/20 0.33
CHRM1 P11229 1/20 0.33
RARG P13631 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3671001 0.87 KDM4E (0.44) KDM4EXBP1ALDH1A1KMT2AHPGD
SCHEMBL3671203 0.80 PKM (0.34) KDM2BFASN
SCHEMBL3672637 0.80 KDM2B (0.35) KDM2BKDM4EXBP1ALDH1A1RXRA
SCHEMBL3672849 0.78 KDM2B (0.36) KDM2BKDM4EXBP1ALDH1A1RXRA
SCHEMBL3677117 0.78 FASN (0.36) KDM2BKDM4EALDH1A1KMT2AMEN1
SCHEMBL256587 0.78 ALDH1A1 (0.45) KDM4EALDH1A1KMT2AMEN1SLC6A2
SCHEMBL3670675 0.77 PKM (0.41) KDM2BKDM4EXBP1ALDH1A1KMT2A
SCHEMBL23866010 0.75 HPGD (0.51) KMT2AMEN1SLC6A2SLC6A3KCNH2
SCHEMBL3669312 0.75 MRGPRX4 (0.37) KDM2BKDM4EXBP1ALDH1A1KMT2A
SCHEMBL3792897 0.75 FASN (0.34) KDM2BKDM4EALDH1A1KMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7642296-B2 2-hydroxy-1-(4-hydroxymethyl-phenyl)-2-methyl-propan-1-one, have higher reactivity at the benzylic hydroxy group and do not have a tendency to yellowing; photocurable composition for pigmented or non-pigmented varnish surface coatings CIBA SPECIALTY CHEMICALS CORPORATION (US) 2010-01-05 US claimed
US-20070240609-A1 Photoinitiators IGM GROUP B.V. (NL) 2007-10-18 US claimed
EP-1763499-B1 NEW PHOTOINITIATORS CIBA SC HOLDING AG (CH) 2007-09-26 EP claimed
EP-1763499-A1 NEW PHOTOINITIATORS CIBA SPECIALTY CHEMICALS HOLDING INC. Patent Departement (CH) 2007-03-21 EP claimed
WO-2005100292-A1 NEW PHOTOINITIATORS CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2005-10-27 WO claimed
US-7642296-B2 2-hydroxy-1-(4-hydroxymethyl-phenyl)-2-methyl-propan-1-one, have higher reactivity at the benzylic hydroxy group and do not have a tendency to yellowing; photocurable composition for pigmented or non-pigmented varnish surface coatings CIBA SPECIALTY CHEMICALS CORPORATION (US) 2010-01-05 US disclosed
US-20070240609-A1 Photoinitiators IGM GROUP B.V. (NL) 2007-10-18 US disclosed
EP-1763499-B1 NEW PHOTOINITIATORS CIBA SC HOLDING AG (CH) 2007-09-26 EP disclosed
EP-1763499-A1 NEW PHOTOINITIATORS CIBA SPECIALTY CHEMICALS HOLDING INC. Patent Departement (CH) 2007-03-21 EP disclosed
WO-2005100292-A1 NEW PHOTOINITIATORS CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2005-10-27 WO disclosed