Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.37 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.37 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.37 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TOP2A | P11388 | 2/20 | 0.35 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3511513 | 0.77 | TOP2A (0.41) | MAPK1ALDH1A1HPGDTOP2ATOP2B | |
| SCHEMBL5690211 | 0.76 | ATM (0.35) | TOP2ATOP2BLMNAHDAC1HDAC8 | |
| SCHEMBL1687312 | 0.75 | ALDH1A1 (0.60) | MAPK1CYP3A4ALDH1A1LMNAHTT | |
| SCHEMBL19604769 | 0.73 | NPC1 (0.36) | ALDH1A1HPGDLMNANPSR1 | |
| SCHEMBL946915 | 0.72 | ALDH1A1 (0.46) | ALDH1A1HPGDNPSR1 | |
| SCHEMBL6631249 | 0.72 | HDAC4 (0.38) | CYP3A4L3MBTL1 | |
| SCHEMBL12826607 | 0.70 | RAB9A (0.51) | LMNA | |
| SCHEMBL27693705 | 0.70 | FAAH (0.37) | ALDH1A1HPGDLMNANPSR1 | |
| SCHEMBL3507124 | 0.69 | PTGES (0.41) | TOP2ATOP2BLMNA | |
| SCHEMBL13269952 | 0.69 | PTGES (0.43) | HPGDL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2166846-A1 | INHIBITORS OF JANUS KINASES | Merck Sharp & Dohme Corp. (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008156726-A1 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2008-12-24 | — | — | WO | disclosed |