Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNMT1 | P26358 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1679677 | 0.98 | DNMT1 (0.59) | DNMT1ALDH1A1KMT2AMEN1L3MBTL1 | |
| SCHEMBL6551466 | 0.95 | DNMT1 (0.57) | DNMT1ALDH1A1KMT2AMEN1L3MBTL1 | |
| SCHEMBL3818647 | 0.95 | DNMT1 (0.57) | DNMT1ALDH1A1KMT2AMEN1L3MBTL1 | |
| SCHEMBL8705730 | 0.85 | ALDH1A1 (0.59) | DNMT1ALDH1A1KMT2AMEN1L3MBTL1 | |
| P-Xylene SCHEMBL28218862 | 0.77 | GAA (0.55) | DNMT1ALDH1A1KMT2AMEN1CYP2C9 | |
| SCHEMBL11331028 | 0.76 | SMN1; SMN2 (0.50) | ALDH1A1KMT2AMEN1L3MBTL1HPGD | |
| SCHEMBL29009430 | 0.74 | CYP2C9 (0.50) | ALDH1A1KMT2AMEN1L3MBTL1HPGD | |
| SCHEMBL3240261 | 0.74 | ALDH1A1 (0.56) | ALDH1A1KMT2AMEN1L3MBTL1HPGD | |
| SCHEMBL28785463 | 0.74 | ALDH1A1 (0.41) | DNMT1ALDH1A1KMT2AMEN1L3MBTL1 | |
| P-Xylene SCHEMBL27791681 | 0.74 | GAA (0.58) | DNMT1ALDH1A1KMT2AMEN1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3831841-A1 | NOVEL CYCLOSPORIN DERIVATIVES AND USES THEREOF | S&T Global Inc. (US) | 2021-06-09 | — | — | EP | disclosed |
| US-20190151403-A1 | NOVEL CYCLOSPORIN DERIVATIVES AND USES THEREOF | S&T GLOBAL INC. | 2019-05-23 | — | — | US | disclosed |
| EP-3458470-A1 | NOVEL CYCLOSPORIN DERIVATIVES AND USES THEREOF | S&T Global Inc. (US) | 2019-03-27 | — | — | EP | disclosed |
| US-10077241-B2 | Tetrahydro-benzoimidazolyl modulators of TGR5 | JANSEN PHARMACEUTICA NV (BE) | 2018-09-18 | — | — | US | disclosed |
| WO-2017200984-A1 | NOVEL CYCLOSPORIN DERIVATIVES AND USES THEREOF | S&T GLOBAL INC. (US) | 2017-11-23 | — | — | WO | disclosed |
| US-20170101445-A1 | NOVEL CYCLOSPORIN DERIVATIVES FOR THE TREATMENT AND PREVENTION OF A VIRAL INFECTION | S&T GLOBAL INC. | 2017-04-13 | — | — | US | disclosed |
| US-9573978-B2 | Cyclosporin derivatives for the treatment and prevention of a viral infection | S&T GLOBAL, INC. (US) | 2017-02-21 | — | — | US | disclosed |
| US-20170029381-A1 | TETRAHYDRO-BENZOIMIDAZOLYL MODULATORS OF TGR5 | JANSSEN PHARMACEUTICA NV (BE) | 2017-02-02 | — | — | US | disclosed |
| US-20160052972-A1 | NOVEL CYCLOSPORIN DERIVATIVES FOR THE TREATMENT AND PREVENTION OF A VIRAL INFECTION | S&T GLOBAL INC. | 2016-02-25 | — | — | US | disclosed |
| US-9217015-B2 | Cyclosporin derivatives for the treatment and prevention of a viral infection | S&T GLOBAL INC. (US) | 2015-12-22 | — | — | US | disclosed |
| US-6306863-B1 | TREATMENT OF ASTHMA WITH CAMPOUNDS | ASTRAZENECA AB (SE) | 2001-10-23 | — | — | US | disclosed |
| US-6229013-B1 | PRODUCED BY HYDROGENATION AND DEHALOGENATION IN THE PRESENCE OF A CATALYST; ANTIINFLAMMATORY AGENTS, IMMUNOSUPRESSANTS, ANTIPROLIFERATIVE AGENTS, ANTICARCINOGENIC AGENTS, AND TREATMENT OF RHEUMATIC DISEASE | ASTRAZENECA UK LIMITED (GB) | 2001-05-08 | — | — | US | disclosed |
| US-6211368-B1 | HYDROLYSIS OF CORRESPONDING ESTER | ASTRAZENECA UK LIMITED (GB) | 2001-04-03 | — | — | US | disclosed |
| US-6180635-B1 | NOVEL THIENO(2,3-D)PYRIMIDINEDIONES WHICH EXHIBIT PHARMACOLOGICAL ACTIVITY, IN PARTICULAR IMMUNOSUPPRESSIVE ACTIVITY; TREATING ALLOGRAFT REJECTION | ASTRAZENECA UK LIMITED (GB) | 2001-01-30 | — | — | US | disclosed |
| US-6166206-A | Pyrrolo[3,4-D]Pyrimidinone derivatives and their use as medicaments | ASTRAZENECA UK LIMITED (GB) | 2000-12-26 | — | — | US | disclosed |
| US-6046204-A | Pyrrolo[3,4-D] pyrimidinone derivatives and their use as medicaments | ASTRA PHARMACEUTICALS LIMITED (GB) | 2000-04-04 | — | — | US | disclosed |
| US-6028074-A | FOR TREATING ALLOGRAFT REJECTION | ASTRA PHARMACEUTICALS, LTD. (GB) | 2000-02-22 | — | — | US | disclosed |
| EP-0495253-B1 | Method for the photographic production of silver images | AGFA GEVAERT NV (BE) | 1995-05-10 | — | — | EP | disclosed |
| US-5266442-A | Method for increasing the contrast of photographic silver images | AGFA-GEVAERT N.V. (BE) | 1993-11-30 | — | — | US | disclosed |
| EP-0495253-A1 | Method for the photographic production of silver images | AGFA-GEVAERT N.V. (BE) | 1992-07-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160052972-A1 | NOVEL CYCLOSPORIN DERIVATIVES FOR THE TREATMENT AND PREVENTION OF A VIRAL INFECTION | HAVCR2, TSLP, ICOS | DNMT1 3143/4885ALDH1A1 3167/4885KMT2A 4220/4885 |
| US-20190151403-A1 | NOVEL CYCLOSPORIN DERIVATIVES AND USES THEREOF | MALT1, MYLK2, FKBP1B | DNMT1 2069/4885ALDH1A1 2805/4885KMT2A 4599/4885 |
| US-10077241-B2 | Tetrahydro-benzoimidazolyl modulators of TGR5 | GLRA1, GRM5, TRHR | DNMT1 3128/4885ALDH1A1 2911/4885KMT2A 1976/4885 |
| US-20170029381-A1 | TETRAHYDRO-BENZOIMIDAZOLYL MODULATORS OF TGR5 | GLRA1, GRM5, TRHR | DNMT1 3128/4885ALDH1A1 2911/4885KMT2A 1976/4885 |
| US-20170101445-A1 | NOVEL CYCLOSPORIN DERIVATIVES FOR THE TREATMENT AND PREVENTION OF A VIRAL INFECTION | HAVCR2, TSLP, HLA-DRB1 | DNMT1 3242/4885ALDH1A1 3272/4885KMT2A 4455/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.