SCHEMBL3676570

SCHEMBL3676570

Cc1c(N)cc(F)c(N)c1C

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.33
CYP3A4 P08684 3/20 0.32
TSHR P16473 3/20 0.32
TDP1 Q9NUW8 2/20 0.32
MAPK1 P28482 1/20 0.32
PIK3CA P42336 1/20 0.32
TP53 P04637 1/20 0.32
HDAC1 Q13547 1/20 0.31
HDAC6 Q9UBN7 1/20 0.31
KDM4E B2RXH2 1/20 0.31
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31
CYP1A2 P05177 1/20 0.31
ALOX15 P16050 1/20 0.31
CASP7 P55210 1/20 0.31
HIF1A Q16665 1/20 0.31
HSD17B10 Q99714 1/20 0.31
CA1 P00915 1/20 0.30
CA2 P00918 1/20 0.30
CA9 Q16790 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25162229 0.80 ALDH1A1 (0.36) ALDH1A1CYP3A4TSHRTDP1MAPK1
SCHEMBL3674167 0.79 ALDH1A1 (0.33) ALDH1A1CYP3A4TSHRTDP1MAPK1
SCHEMBL21908936 0.75 ACHE (0.40) ALDH1A1CYP3A4TSHRTDP1HDAC1
SCHEMBL3668658 0.75 NOS3 (0.31) ALDH1A1CYP1A2ALOX15CASP7HIF1A
SCHEMBL7073277 0.74 CA1 (0.36) ALDH1A1CYP3A4TSHRTDP1TP53
SCHEMBL24717974 0.74 ALDH1A1 (0.33) ALDH1A1CYP3A4TSHRTDP1MAPK1
SCHEMBL4895474 0.74 ALDH1A1 (0.33) ALDH1A1CYP3A4TSHRTDP1MAPK1
Hydrochloric Acid SCHEMBL21811688 0.73 MAPT (0.41) ALDH1A1CYP3A4TSHRTDP1MAPK1
SCHEMBL459701 0.72 ALDH1A1 (0.48) ALDH1A1CYP3A4TSHRTDP1MAPK1
SCHEMBL30688718 0.72 ALDH1A1 (0.36) ALDH1A1HDAC1HDAC6CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1426392-B1 COMPOSITION FOR OPTICAL MATERIAL MITSUBISHI GAS CHEMICAL CO (JP) 2010-02-24 EP disclosed
US-6960640-B2 Composition for optical material MITSUBISHI GAS CHEMICAL CO., LTD. (JP) 2005-11-01 US disclosed
US-20040147708-A1 Composition for optical material MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2004-07-29 US disclosed
EP-1426392-A1 COMPOSITION FOR OPTICAL MATERIAL MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2004-06-09 EP disclosed