Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 3/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.39 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ALPL | P05186 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1513972 | 0.83 | GSK3B (0.52) | MAPTKDM4EGSK3BDPP4DPP8 | |
| SCHEMBL3676712 | 0.80 | KDM4E (0.44) | MAPTKDM4EDPP4DPP8DPP9 | |
| SCHEMBL12762528 | 0.78 | GSK3B (0.45) | KDM4EGSK3BDPP4DPP8LMNA | |
| SCHEMBL14237167 | 0.77 | GSK3B (0.72) | MAPTKDM4EGSK3BDPP4DPP8 | |
| SCHEMBL1110696 | 0.71 | ALDH1A1 (0.46) | MAPTKDM4ETSHRLMNACNR1 | |
| SCHEMBL167398 | 0.70 | SIGMAR1 (0.52) | MAPTKDM4ELMNACNR1GABRA2 | |
| SCHEMBL1514053 | 0.69 | LMNA (0.47) | MAPTKDM4EGSK3BLMNACNR1 | |
| SCHEMBL10584537 | 0.67 | GABRA2 (0.45) | MAPTKDM4ELMNACNR1GABRA2 | |
| SCHEMBL168942 | 0.67 | SLC5A1 (0.48) | MAPTKDM4ELMNACNR1GABRA2 | |
| SCHEMBL376669 | 0.67 | KDM4E (0.45) | MAPTKDM4ELMNACNR1GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2176264-B1 | IMIDAZO-, PYRAZOLOPYRAZINES AND IMIDAZOTRIAZINES FOR TREATING HEMATOLOGICAL DISORDERS | BAYER IP GMBH (DE) | 2012-12-19 | — | — | EP | disclosed |
| EP-2176264-A1 | IMIDAZO-, PYRAZOLOPYRAZINES AND IMIDAZOTRIAZINES AND THEIR USE | Bayer Schering Pharma AG (DE) | 2010-04-21 | — | — | EP | disclosed |
| WO-2009007029-A1 | IMIDAZO-, PYRAZOLOPYRAZINES AND IMIDAZOTRIAZINES AND THEIR USE | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-01-15 | — | — | WO | disclosed |