Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ERN1 | O75460 | 1/20 | 0.37 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.36 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL366033 | 0.90 | NPC1 (0.40) | NPC1GAAATMRXFP1CYP19A1 | |
| SCHEMBL367765 | 0.89 | NPC1 (0.43) | NPC1GAAATMRXFP1KDM4E | |
| SCHEMBL365272 | 0.87 | CA12 (0.42) | NPC1GAAATMRXFP1KDM4E | |
| SCHEMBL365020 | 0.87 | BAZ2B (0.43) | NPC1GAAATMRXFP1KDM4E | |
| SCHEMBL364537 | 0.85 | BAZ2B (0.38) | CYP19A1KDM4EALDH1A1MAPTERN1 | |
| SCHEMBL367749 | 0.82 | NPC1 (0.41) | NPC1GAAATMRXFP1KDM4E | |
| SCHEMBL365489 | 0.82 | KMT2A (0.36) | ALDH1A1RAB9A | |
| SCHEMBL365191 | 0.82 | MKNK2 (0.40) | NPC1GAAATMRXFP1KDM4E | |
| SCHEMBL365916 | 0.80 | KDM4E (0.40) | GAAKDM4EALDH1A1MAPTERN1 | |
| SCHEMBL365175 | 0.78 | NPC1 (0.43) | NPC1GAAATMRXFP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |