Phenylalanine

Phenylalanine

SCHEMBL367780

N[C@@H](Cc1ccccc1)C(=O)O.O=C(O)c1nccs1

nearest known ligand 0.61

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC7A5 Q01650 4/20 0.61
PTGS1 P23219 2/20 0.61
ALPI P09923 1/20 0.61
PKM P14618 1/20 0.61
XIAP P98170 1/20 0.61
PLA2G4A P47712 1/20 0.49
CES1 P23141 1/20 0.48
SLC1A3 P43003 2/20 0.47
SLC1A2 P43004 2/20 0.47
SLC1A1 P43005 2/20 0.47
HSD17B10 Q99714 2/20 0.46
GRIA2 P42262 2/20 0.45
SLC15A1 P46059 1/20 0.43
KDM4E B2RXH2 1/20 0.43
USP2 O75604 1/20 0.43
EGFR P00533 1/20 0.43
LCK P06239 1/20 0.43
FYN P06241 1/20 0.43
ADORA3 P0DMS8 1/20 0.43
ALOX15 P16050 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Serine SCHEMBL359195 0.81 ALDH1A1 (0.44) SLC7A5PKMPLA2G4ACES1SLC1A1
Serine SCHEMBL359193 0.81 ALDH1A1 (0.44) SLC7A5PKMPLA2G4ACES1SLC1A1
SCHEMBL367781 0.80 PLA2G4A (0.46) SLC7A5PTGS1ALPIPKMXIAP
Cysteine SCHEMBL357652 0.80 PTGS1 (0.50) SLC7A5PTGS1PKMPLA2G4ACES1
Cysteine SCHEMBL1986796 0.80 PTGS1 (0.50) SLC7A5PTGS1PKMPLA2G4ACES1
D-Phenylalanine SCHEMBL28177701 0.78 SLC7A5 (0.92) SLC7A5PTGS1ALPIPKMXIAP
SCHEMBL23159186 0.78 SLC7A5 (1.00) SLC7A5PTGS1ALPIPKMXIAP
Dl-Phenylalanine SCHEMBL385804 0.78 SLC7A5 (1.00) SLC7A5PTGS1ALPIPKMXIAP
Dl-Phenylalanine SCHEMBL16398196 0.78 SLC7A5 (1.00) SLC7A5PTGS1ALPIPKMXIAP
Phenylalanine SCHEMBL16398197 0.78 SLC7A5 (1.00) SLC7A5PTGS1ALPIPKMXIAP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 100 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3334498-B1 METHODS OF TREATING VOLUME DEPLETION AND KIDNEY INJURY UNIV COLUMBIA (US) 2023-06-07 EP disclosed
US-11119104-B2 Methods of treating volume depletion and kidney injury THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2021-09-14 US disclosed
EP-3334498-A1 METHODS OF TREATING VOLUME DEPLETION AND KIDNEY INJURY The Trustees of Columbia University in the City of New York (US) 2018-06-20 EP disclosed
EP-2593472-B1 ANCESTRAL PROTEINS UNIV COLUMBIA (US) 2018-05-16 EP disclosed
US-9880088-B2 Force-clamp spectrometer with functionalized cantilever tip THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2018-01-30 US disclosed
US-20180016562-A1 ANCESTRAL PROTEINS NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR 2018-01-18 US disclosed
US-9682123-B2 Methods of treating metabolic disease THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2017-06-20 US disclosed
WO-2017027858-A1 METHODS OF TREATING VOLUME DEPLETION AND KIDNEY INJURY THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2017-02-16 WO disclosed
US-20150190466-A1 METHODS OF TREATING METABOLIC DISEASE NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR 2015-07-09 US disclosed
US-20130252307-A1 ANCESTRAL PROTEINS GEORGIA TECH RESEARCH CORPORATION (US) 2013-09-26 US disclosed
WO-2003020897-A2 COMPOSITIONS AND METHODS RELATING TO OVARY SPECIFIC GENES AND PROTEINS DIADEXUS, INC. (US) 2003-03-13 WO disclosed
WO-2003020934-A1 COMPOSITIONS AND METHODS RELATING TO COLON SPECIFIC GENES AND PROTEINS DIADEXUS, INC. (US) 2003-03-13 WO disclosed
WO-2003020899-A2 COMPOSITIONS AND METHODS RELATING TO LUNG SPECIFIC GENES AND PROTEINS DIADEXUS, INC. (US) 2003-03-13 WO disclosed
WO-2003020900-A2 COMPOSITIONS AND METHODS RELATING TO BREAST SPECIFIC GENES AND PROTEINS DIADEXUS, INC. (US) 2003-03-13 WO disclosed
WO-2003020953-A2 COMPOSITIONS AND METHODS RELATING TO COLON SPECIFIC GENES AND PROTEINS DIADEXUS, INC. (US) 2003-03-13 WO disclosed
WO-2003020901-A2 COMPOSITIONS AND METHODS RELATING TO PROSTATE SPECIFIC GENES AND PROTEINS DIADEXUS, INC. (US) 2003-03-13 WO disclosed
US-20020102610-A1 Automated identification of peptides OXFORD GLYCOSCIENCES (UK) LTD. (GB) 2002-08-01 US disclosed
US-20020055186-A1 Detection of peptides OXFORD GLYCOSCIENCES (UK) LTD. 2002-05-09 US disclosed
WO-2002025287-A2 DETECTION OF PEPTIDES OXFORD GLYCOSCIENCES (UK) LTD. (GB) 2002-03-28 WO disclosed
WO-2002021139-A2 AUTOMATED IDENTIFICATION OF PEPTIDES OXFORD GLYCOSCIENCES (UK) LTD. (GB) 2002-03-14 WO disclosed