Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
| ▸ | HPGDS | O60760 | 2/20 | 0.49 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.47 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.47 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.47 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.47 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.47 |
| ▸ | PRKAG2 | Q9UGJ0 | 2/20 | 0.47 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | P4HTM | Q9NXG6 | 3/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL841649 | 0.95 | MAPK1 (0.56) | MAPK1KDM4EL3MBTL1HPGDSPRKAB2 | |
| SCHEMBL16047520 | 0.86 | MAPK1 (0.64) | MAPK1KDM4EL3MBTL1HPGDSPRKAB2 | |
| SCHEMBL64700 | 0.79 | MAPK1 (1.00) | MAPK1KDM4EL3MBTL1P4HTM | |
| SCHEMBL5483603 | 0.78 | NAMPT (0.51) | KDM4EHPGDSNPC1RAB9AMEN1 | |
| Hydrochloric Acid SCHEMBL6553707 | 0.78 | MAPK1 (0.96) | MAPK1KDM4EL3MBTL1P4HTM | |
| SCHEMBL16048351 | 0.77 | HCAR3 (0.59) | KDM4EPRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL518736 | 0.72 | PRKAA2 (0.70) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL10269250 | 0.71 | PRKAA2 (0.69) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL600512 | 0.71 | MAPK1 (0.74) | MAPK1KDM4EL3MBTL1NPC1RAB9A | |
| SCHEMBL5497348 | 0.71 | RAB9A (0.56) | KDM4ENPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2158198-A2 | NOVEL N- (8HETEROARYLTETRAHYDRONAPHTALENE-2YL) OR N- (5- HETEROARYLCHROMANE-3-YL) CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | AstraZeneca AB (SE) | 2010-03-03 | — | — | EP | disclosed |
| WO-2008130320-A2 | NOVEL N- (8-HETEROARYLTETRAHYDRONAPHTALENE-2YL) OR N- (5- HETEROARYLCHROMANE-3-YL) CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |