Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 4/20 | 0.67 |
| ▸ | HTR2A | P28223 | 1/20 | 0.67 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.67 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.56 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.50 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.48 |
| ▸ | HTR3B | O95264 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | HTR3A | P46098 | 1/20 | 0.48 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.48 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8597079 | 0.98 | HTR2C (0.65) | HTR2CHTR2ASLC6A4EPHX2PRKD1 | |
| SCHEMBL30822012 | 0.83 | CYP1A2 (0.53) | HTR2CHTR2ASLC6A4KDM4EALDH1A1 | |
| SCHEMBL10495676 | 0.81 | HTR2C (0.68) | HTR2CHTR2ASLC6A4EPHX2PLD1 | |
| SCHEMBL1045944 | 0.80 | HTR2A (1.00) | HTR2CHTR2ASLC6A4EPHX2PLD1 | |
| SCHEMBL30040877 | 0.80 | HTR2C (1.00) | HTR2CHTR2AKDM4EALDH1A1HTR3E | |
| SCHEMBL2076366 | 0.80 | HTR2C (1.00) | HTR2CHTR2AKDM4EALDH1A1HTR3E | |
| SCHEMBL3688963 | 0.80 | HRH4 (0.67) | HTR2CKDM4EHTR3EHTR3BHTR1A | |
| Hydrochloric Acid SCHEMBL1532881 | 0.79 | HTR2C (0.97) | HTR2CHTR2AKDM4EALDH1A1HTR3E | |
| Hydrochloric Acid SCHEMBL1048620 | 0.79 | HTR2A (0.97) | HTR2CHTR2ASLC6A4EPHX2KDM4E | |
| SCHEMBL30600701 | 0.78 | GRM4 (0.52) | HTR2CHTR2ASLC6A4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4866176-A | ANTIINFLAMMATORY, ANTIARRHYTHMIA, CARDIOTONIC AGENTS | SS PHARMACEUTICAL CO., LTD. (JP) | 1989-09-12 | — | — | US | claimed |
| EP-0256556-A1 | 8-Piperazinyl-1,7-naphthyridine derivatives | SS PHARMACEUTICAL CO., LTD. (JP) | 1988-02-24 | — | — | EP | claimed |
| EP-1724267-B1 | PYRIMIDINE DERIVATIVE | ASKA PHARM CO LTD (JP) | 2013-11-06 | — | — | EP | disclosed |
| EP-1724267-B1 | PYRIMIDINE DERIVATIVE | ASKA PHARM CO LTD (JP) | 2013-11-06 | — | — | EP | disclosed |
| US-7799775-B2 | such as 3-amino-5,6-dimethyl-2-[3-(4-quinolin-2-ylpiperazin-1-yl)propylthio]-3H-thieno[2,3-d]pyrimidin-4-one, having serotonin receptor modulatory activity, used for treating irritable bowel syndrome | ASKA PHARMACEUTICAL CO., LTD. (JP) | 2010-09-21 | — | — | US | disclosed |
| US-7799775-B2 | such as 3-amino-5,6-dimethyl-2-[3-(4-quinolin-2-ylpiperazin-1-yl)propylthio]-3H-thieno[2,3-d]pyrimidin-4-one, having serotonin receptor modulatory activity, used for treating irritable bowel syndrome | ASKA PHARMACEUTICAL CO., LTD. (JP) | 2010-09-21 | — | — | US | disclosed |
| US-7799775-B2 | such as 3-amino-5,6-dimethyl-2-[3-(4-quinolin-2-ylpiperazin-1-yl)propylthio]-3H-thieno[2,3-d]pyrimidin-4-one, having serotonin receptor modulatory activity, used for treating irritable bowel syndrome | ASKA PHARMACEUTICAL CO., LTD. (JP) | 2010-09-21 | — | — | US | disclosed |
| US-20070197551-A1 | Pyrimidine derivatives | ASKA PHARMACEUTICAL CO., LTD. (JP) | 2007-08-23 | — | — | US | disclosed |
| US-20070197551-A1 | Pyrimidine derivatives | ASKA PHARMACEUTICAL CO., LTD. (JP) | 2007-08-23 | — | — | US | disclosed |
| US-20070197551-A1 | Pyrimidine derivatives | ASKA PHARMACEUTICAL CO., LTD. (JP) | 2007-08-23 | — | — | US | disclosed |
| EP-1724267-A1 | PYRIMIDINE DERIVATIVE | ASKA Pharmaceutical Co., Ltd. (JP) | 2006-11-22 | — | — | EP | disclosed |
| US-4866176-A | ANTIINFLAMMATORY, ANTIARRHYTHMIA, CARDIOTONIC AGENTS | SS PHARMACEUTICAL CO., LTD. (JP) | 1989-09-12 | — | — | US | disclosed |
| US-4866176-A | ANTIINFLAMMATORY, ANTIARRHYTHMIA, CARDIOTONIC AGENTS | SS PHARMACEUTICAL CO., LTD. (JP) | 1989-09-12 | — | — | US | disclosed |
| US-4866176-A | ANTIINFLAMMATORY, ANTIARRHYTHMIA, CARDIOTONIC AGENTS | SS PHARMACEUTICAL CO., LTD. (JP) | 1989-09-12 | — | — | US | disclosed |
| EP-0256556-A1 | 8-Piperazinyl-1,7-naphthyridine derivatives | SS PHARMACEUTICAL CO., LTD. (JP) | 1988-02-24 | — | — | EP | disclosed |
| EP-0256556-A1 | 8-Piperazinyl-1,7-naphthyridine derivatives | SS PHARMACEUTICAL CO., LTD. (JP) | 1988-02-24 | — | — | EP | disclosed |
| EP-0256556-A1 | 8-Piperazinyl-1,7-naphthyridine derivatives | SS PHARMACEUTICAL CO., LTD. (JP) | 1988-02-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197551-A1 | Pyrimidine derivatives | HTR3B, HTR3A, HTR1A | HTR2C 14/4885HTR2A 12/4885SLC6A4 41/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.