Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 12/20 | 0.72 |
| ▸ | CTSL | P07711 | 8/20 | 0.59 |
| ▸ | CTSS | P25774 | 3/20 | 0.55 |
| ▸ | CTSB | P07858 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5373982 | 0.92 | CTSK (0.73) | CTSKCTSLCTSSCTSB | |
| SCHEMBL3681722 | 0.92 | CTSK (0.73) | CTSKCTSLCTSSCTSB | |
| SCHEMBL3684689 | 0.90 | CTSK (0.68) | CTSKCTSLCTSSCTSB | |
| SCHEMBL13446020 | 0.88 | CTSK (0.82) | CTSKCTSLCTSSCTSB | |
| SCHEMBL3681981 | 0.87 | CTSK (0.67) | CTSKCTSLCTSSCTSB | |
| SCHEMBL3682719 | 0.87 | CTSK (0.67) | CTSKCTSLCTSSCTSB | |
| SCHEMBL3675860 | 0.87 | CTSK (0.66) | CTSKCTSLCTSSCTSB | |
| SCHEMBL3677423 | 0.87 | CTSK (0.71) | CTSKCTSLCTSSCTSB | |
| SCHEMBL2155930 | 0.85 | CTSK (0.77) | CTSKCTSLCTSSCTSB | |
| SCHEMBL3682967 | 0.85 | CTSK (0.78) | CTSKCTSLCTSSCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1694647-B1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK CANADA INC (CA) | 2016-11-09 | — | — | EP | claimed |
| US-7687524-B2 | Cathepsin cysteine protease inhibitors | MERCK FROSST CANADA & CO. (CA) | 2010-03-30 | — | — | US | claimed |
| US-20070099893-A1 | Cathepsin cysteine protease inhibitors | MERCK CANADA INC. (CA) | 2007-05-03 | — | — | US | claimed |
| EP-1694647-B1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK CANADA INC (CA) | 2016-11-09 | — | — | EP | disclosed |
| US-7687524-B2 | Cathepsin cysteine protease inhibitors | MERCK FROSST CANADA & CO. (CA) | 2010-03-30 | — | — | US | disclosed |
| US-20070099893-A1 | Cathepsin cysteine protease inhibitors | MERCK CANADA INC. (CA) | 2007-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070099893-A1 | Cathepsin cysteine protease inhibitors | CTSB, CTSS, CTSZ | CTSK 4/4885CTSL 8/4885CTSS 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.