SCHEMBL3686883

SCHEMBL3686883

COc1cccc2c(C(O)CN3CCC(NC(C4=CC=CCC4)C4=COC=CO4)C3)ccnc12

nearest known ligand 0.34

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 2/20 0.34
SLC2A1 P11166 11/20 0.33
SIGMAR1 Q99720 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5254100 0.96 KCNH2 (0.36) KCNH2SLC2A1SIGMAR1
SCHEMBL5262026 0.86 KCNH2 (0.32) KCNH2
SCHEMBL3695685 0.86 DRD4 (0.30)
SCHEMBL5650870 0.85 KCNH2 (0.49) KCNH2SLC2A1
SCHEMBL3697776 0.85 SLC2A1 (0.38) KCNH2SLC2A1SIGMAR1
SCHEMBL3694994 0.82
SCHEMBL5255791 0.81 KCNH2 (0.52) KCNH2SLC2A1
SCHEMBL5254382 0.80 KCNH2 (0.51) KCNH2SLC2A1
SCHEMBL3694128 0.80 HTR1A (0.32)
SCHEMBL3775157 0.80 KCNH2 (0.41) KCNH2SLC2A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2239260-A1 Novel compounds with antibacterial activity Morphochem Aktiengesellschaft Für Kombinatorische Chemie (DE) 2010-10-13 EP disclosed
EP-1551829-A2 NOVEL COMPOUNDS WITH ANTIBACTERIAL ACTIVITY Morphochem Aktiengesellschaft Für Kombinatorische Chemie (DE) 2005-07-13 EP disclosed
WO-2004035569-A2 NOVEL COMPOUNDS WITH ANTIBACTERIAL ACTIVITY Morphochem Aktiengesellschaft für kombinatorische Chemie (DE) 2004-04-29 WO disclosed