Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.38 |
| ▸ | RARB | P10826 | 7/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | RARA | P10276 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | GPR3 | P46089 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TOP2A | P11388 | 1/20 | 0.33 |
| ▸ | TNNC1 | P63316 | 2/20 | 0.32 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3690696 | 0.96 | HSD11B1 (0.38) | HSD11B1RARBTOP2A | |
| Hydrochloric Acid SCHEMBL3687089 | 0.92 | EDNRB (0.30) | — | |
| Hydrochloric Acid SCHEMBL3687227 | 0.87 | EDNRB (0.38) | — | |
| Hydrochloric Acid SCHEMBL3689983 | 0.86 | HSD17B10 (0.34) | HSD11B1RARBMEN1ALDH1A1RARA | |
| Hydrochloric Acid SCHEMBL3689637 | 0.85 | HSD17B10 (0.34) | HSD11B1RARBMEN1ALDH1A1RARA | |
| Hydrochloric Acid SCHEMBL3689645 | 0.85 | HSD17B10 (0.34) | HSD11B1RARBMEN1ALDH1A1RARA | |
| Hydrochloric Acid SCHEMBL7938880 | 0.84 | CHRNB2 (0.33) | DRD2 | |
| Hydrochloric Acid SCHEMBL3688616 | 0.84 | DHFR (0.34) | — | |
| Hydrochloric Acid SCHEMBL3692543 | 0.83 | HSD17B10 (0.32) | HSD11B1RARBMEN1ALDH1A1RARA | |
| Hydrochloric Acid SCHEMBL7646741 | 0.83 | HSD11B1 (0.35) | HSD11B1RARBALDH1A1MAPTTOP2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100056737-A1 | Process for manufacturing high to ultra high molecular weight polymers using novel bridged metallocene catalysts | NUTRINOVA NUTRITION SPECIALTIES & FOOD INGREDIENTS GMBH (DE) | 2010-03-04 | — | — | US | disclosed |
| US-20070105712-A1 | Process for manufacturing ultra high molecular weight polymers using novel bridged metallocene catalysts | NUTRINOVA NUTRITION SPECIALTIES & FOOD INGREDIENTS GMBH (DE) | 2007-05-10 | — | — | US | disclosed |