Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPR | P35270 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | CNR1 | P21554 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.47 |
| ▸ | RUVBL1 | Q9Y265 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL309231 | 0.90 | SPR (0.51) | SPRGAACNR1LMNAKDM4E | |
| SCHEMBL1429534 | 0.75 | L3MBTL1 (0.66) | GAACNR1LMNASMN1; SMN2KDM4E | |
| SCHEMBL18711333 | 0.74 | LMNA (0.69) | GAACNR1LMNASMN1; SMN2KDM4E | |
| SCHEMBL9926689 | 0.74 | HPGD (0.70) | LMNASMN1; SMN2KDM4EHPGDALDH1A1 | |
| SCHEMBL1945062 | 0.74 | L3MBTL1 (0.80) | GAACNR1LMNASMN1; SMN2KDM4E | |
| SCHEMBL15100910 | 0.73 | LMNA (0.74) | GAACNR1LMNASMN1; SMN2KDM4E | |
| SCHEMBL9926696 | 0.73 | KDM4E (0.65) | KDM4EHPGDALDH1A1HSD17B10HTT | |
| SCHEMBL4203652 | 0.73 | HPGD (0.72) | LMNASMN1; SMN2KDM4EHPGDALDH1A1 | |
| SCHEMBL9926550 | 0.73 | MAPT (0.64) | LMNASMN1; SMN2KDM4EHPGDALDH1A1 | |
| SCHEMBL18701978 | 0.72 | LMNA (0.66) | GAACNR1LMNASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2313413-B1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES | CONVERGENCE PHARMACEUTICALS (GB) | 2012-05-16 | — | — | EP | claimed |
| EP-2313413-B1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES | CONVERGENCE PHARMACEUTICALS (GB) | 2012-05-16 | — | — | EP | disclosed |