Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Milrinone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A known ✓ | Q14432 | 8/20 | 0.75 |
| ▸ | PDE3B | Q13370 | 7/20 | 0.75 |
| ▸ | HPGD | P15428 | 3/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.75 |
| ▸ | PDE4A | P27815 | 3/20 | 0.75 |
| ▸ | BLM | P54132 | 2/20 | 0.75 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.75 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.75 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.75 |
| ▸ | PDE5A | O76074 | 1/20 | 0.75 |
| ▸ | LMNA | P02545 | 1/20 | 0.75 |
| ▸ | TSHR | P16473 | 1/20 | 0.75 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.75 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.75 |
| ▸ | GALR3 | O60755 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | PDE2A | O00408 | 1/20 | 0.55 |
| ▸ | PDE1A | P54750 | 1/20 | 0.55 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Milrinone SCHEMBL42338 | 0.91 | PDE3A (0.79) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL3463564 | 0.91 | PDE3A (0.79) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL9247989 | 0.87 | PDE3A (1.00) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL9309054 | 0.87 | PDE3A (1.00) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL9301167 | 0.87 | PDE3A (1.00) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL36947 | 0.87 | PDE3A (1.00) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL28184205 | 0.85 | PDE3A (0.97) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL9132559 | 0.84 | PDE3A (0.94) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL1160021 | 0.84 | PDE3A (0.94) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL8578994 | 0.81 | PDE3A (0.79) | PDE3APDE3BHPGDKDM4EPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 7968 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4691556-A2 | HUMANIZED ANTI-ACTH ANTIBODIES AND USE THEREOF | H. Lundbeck A/S (DK) | 2026-02-11 | — | — | EP | claimed |
| CN-119639388-A | Water-based adhesive for lithium ion battery, and preparation method and application thereof | 拓迪化学(上海)股份有限公司 | 2025-03-18 | — | — | CN | claimed |
| US-20240282425-A1 | AUTHENTICATION METHODS AND SYSTEMS FOR DISPENSED PRESCRIPTIONS | LOW GORDON KEITH (US) | 2024-08-22 | — | — | US | claimed |
| US-20230174641-A1 | ANTI-ACTH ANTIBODIES AND USE THEREOF | H LUNDBECK AS (DK) | 2023-06-08 | — | — | US | claimed |
| EP-3329958-B2 | CATHETER WITH A DUAL LUMEN MONOLITHIC SHAFT | ABBOTT CARDIOVASCULAR SYSTEMS INC (US) | 2022-08-31 | — | — | EP | claimed |
| US-20220211645-A1 | Maximizing Distribution and Minimizing Washout of Injectates in Bone and Method for Enhanced Aspirate Extraction | YALE UNIVERSITY | 2022-07-07 | — | — | US | claimed |
| EP-3965635-A2 | MAXIMIZING DISTRIBUTION AND MINIMIZING WASHOUT OF INJECTATES IN BONE AND METHOD FOR ENHANCED ASPIRATE EXTRACTION | Yale University (US) | 2022-03-16 | — | — | EP | claimed |
| EP-2869882-B2 | CATHETER WITH A DUAL LUMEN MONOLITHIC SHAFT | ABBOTT CARDIOVASCULAR SYSTEMS INC (US) | 2022-01-26 | — | — | EP | claimed |
| EP-3835319-A1 | HUMANIZED ANTI-ACTH ANTIBODIES AND USE THEREOF | Alder Biopharmaceuticals, Inc. (US) | 2021-06-16 | — | — | EP | claimed |
| EP-3753950-A2 | ANTI-PCSK9 ANTIBODIES AND USE THEREOF | H. Lundbeck A/S (DK) | 2020-12-23 | — | — | EP | claimed |
| WO-2002026318-A1 | METHOD AND SYSTEM FOR NERVE STIMULATION AND CARDIAC SENSING PRIOR TO AND DURING A MEDICAL PROCEDURE | MEDTRONIC, INC. (US) | 2002-04-04 | — | — | WO | claimed |
| EP-1176960-A1 | SYNERGISTIC COMBINATION COMPRISING ROFLUMILAST AND A PDE-3 INHIBITOR | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 2002-02-06 | — | — | EP | claimed |
| US-20020003179-A1 | Media milling | SKYEPHARMA AG (CH) | 2002-01-10 | — | — | US | claimed |
| WO-2001092283-A2 | COBALAMIN COMPOUNDS USEFUL AS CARDIOVASCULAR AGENTS AND AS IMAGING AGENTS | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2001-12-06 | — | — | WO | claimed |
| WO-2001085345-A1 | MEDIA MILLING | RTP PHARMA INC. (US) | 2001-11-15 | — | — | WO | claimed |
| US-20010020154-A1 | Protective sheath for catheters | BIGUS STEVE (US) | 2001-09-06 | — | — | US | claimed |
| WO-2001034063-A2 | PROTECTIVE SHEATH FOR CATHETERS | ADVANCED CARDIOVASCULAR SYSTEMS, INC. (US) | 2001-05-17 | — | — | WO | claimed |
| WO-2000066123-A1 | SYNERGISTIC COMBINATION COMPRISING ROFLUMILAST AND A PDE-3 INHIBITOR | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 2000-11-09 | — | — | WO | claimed |
| EP-0537186-A1 | PACKAGING CONTAINER FOLDED OF SHEET MATERIAL. | PI PATENTE GMBH (DE) | 1993-04-21 | — | — | EP | claimed |
| WO-1992000190-A1 | CONTAINER MADE OF SHEET MATERIAL, AND PROCESS FOR RECYCLING THE CONTAINER | FLEISCH- UND VIEHGROSSHANDEL HANS-WERNER UND BERND MEIXNER GMBH (DE) | 1992-01-09 | — | — | WO | claimed |