Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | HTR3A | P46098 | 4/20 | 0.44 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.44 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.44 |
| ▸ | HTR3B | O95264 | 1/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.44 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.44 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6411553 | 0.99 | DYRK1A (0.46) | DYRK1ARAB9ANPC1HTR3AHTR3E | |
| SCHEMBL2087087 | 0.95 | DYRK1A (0.48) | DYRK1ARAB9ANPC1HTR3AHTR3E | |
| SCHEMBL2087552 | 0.79 | GSK3B (0.51) | DYRK1A | |
| SCHEMBL2088254 | 0.79 | GSK3B (0.51) | DYRK1A | |
| SCHEMBL12441936 | 0.79 | NPC1 (0.68) | DYRK1ARAB9ANPC1HTR3AHTR3E | |
| SCHEMBL2086948 | 0.79 | NPC1 (0.68) | DYRK1ARAB9ANPC1HTR3AHTR3E | |
| SCHEMBL2087490 | 0.79 | NPC1 (0.68) | DYRK1ARAB9ANPC1HTR3AHTR3E | |
| SCHEMBL2262277 | 0.78 | RAB9A (0.50) | RAB9ANPC1HTR3AKDM4EALDH1A1 | |
| SCHEMBL3375402 | 0.77 | HTR3A (0.40) | DYRK1ARAB9ANPC1HTR3AHTR3E | |
| SCHEMBL9745866 | 0.77 | HTR3A (0.62) | HTR3AHTR3EHTR3BCHRNB2CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3347012-A1 | MUSCARINIC COMBINATIONS AND THEIR USE FOR COMBATING HYPOCHOLINERGIC DISORDERS OF THE CENTRAL NERVOUS SYSTEM | Chase Pharmaceuticals Corporation (US) | 2018-07-18 | — | — | EP | disclosed |
| EP-3347011-A1 | MUSCARINIC COMBINATION AND ITS USE FOR COMBATING HYPOCHOLINERGIC DISORDERS OF THE CENTRAL NERVOUS SYSTEM | Chase Pharmaceuticals Corporation (US) | 2018-07-18 | — | — | EP | disclosed |
| WO-2017147104-A1 | MUSCARINIC M2-ANTAGONIST COMBINATIONS | CHASE PHARMACEUTICALS CORPORATION (US) | 2017-08-31 | — | — | WO | disclosed |
| WO-2017044714-A1 | MUSCARINIC COMBINATIONS AND THEIR USE FOR COMBATING HYPOCHOLINERGIC DISORDERS OF THE CENTRAL NERVOUS SYSTEM | CHASE PHARMACEUTICALS CORPORATION (US) | 2017-03-16 | — | — | WO | disclosed |
| WO-2017044693-A1 | MUSCARINIC COMBINATION AND ITS USE FOR COMBATING HYPOCHOLINERGIC DISORDERS OF THE CENTRAL NERVOUS SYSTEM | CHASE PHARMACEUTICALS CORPORATION (US) | 2017-03-16 | — | — | WO | disclosed |
| EP-2478099-A1 | METHOD AND COMPOSITION FOR TREATING ALZHEIMER-TYPE DEMENTIA | Chase Pharmaceuticals Corporation (US) | 2012-07-25 | — | — | EP | disclosed |
| WO-2010054003-A2 | METHYLINDAZOLE MODULATORS OF 5-HT3 RECEPTORS | AUSPEX PHARMACEUTICAL, INC. (US) | 2010-05-14 | — | — | WO | disclosed |
| WO-2007054784-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF GRANISETRON HYDROCHLORIDE | ORCHID CHEMICALS & PHARMACEUTICALS LIMITED (IN) | 2007-05-18 | — | — | WO | disclosed |
| EP-0979818-B1 | BENZOIC ACID COMPOUNDS AND MEDICINAL USE THEREOF | MITSUBISHI PHARMA CORP (JP) | 2003-02-19 | — | — | EP | disclosed |
| EP-0882045-A1 | PROCESS FOR THE PREPARATION OF GRANISETRON | SMITHKLINE BEECHAM PLC (GB) | 1998-12-09 | — | — | EP | disclosed |
| WO-1997030049-A1 | PROCESS FOR THE PREPARATION OF GRANISETRON | SMITHKLINE BEECHAM PLC (GB) | 1997-08-21 | — | — | WO | disclosed |
| EP-0748321-A1 | PROCESS FOR THE PREPARATION OF AN INDAZOLE-3-CARBOXAMIDE DERIVATIVE | SMITHKLINE BEECHAM PLC (GB) | 1996-12-18 | — | — | EP | disclosed |
| WO-1995023799-A1 | PROCESS FOR THE PREPARATION OF AN INDAZOLE-3-CARBOXAMIDE DERIVATIVE | SMITHKLINE BEECHAM PLC (GB) | 1995-09-08 | — | — | WO | disclosed |