Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.39 |
| ▸ | SLC16A3 | O15427 | 7/20 | 0.38 |
| ▸ | SLC16A1 | P53985 | 5/20 | 0.38 |
| ▸ | NAMPT | P43490 | 3/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.36 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3703141 | 0.86 | CA1 (0.44) | NFE2L2SLC16A3SLC16A1NAMPTMET | |
| Hydrochloric Acid SCHEMBL3690326 | 0.85 | NFE2L2 (0.42) | NFE2L2NAMPTMETGLO1SLC40A1 | |
| SCHEMBL4125767 | 0.83 | NFE2L2 (0.39) | NFE2L2SLC16A3SLC16A1NAMPTMET | |
| SCHEMBL4125764 | 0.83 | NFE2L2 (0.40) | NFE2L2SLC16A3SLC16A1NAMPTMET | |
| SCHEMBL3694089 | 0.80 | NFE2L2 (0.41) | NFE2L2METMTNR1B | |
| SCHEMBL3705969 | 0.79 | SLC16A3 (0.39) | NFE2L2SLC16A3SLC16A1MET | |
| SCHEMBL3705968 | 0.79 | SLC16A3 (0.39) | NFE2L2SLC16A3SLC16A1MET | |
| SCHEMBL3697370 | 0.77 | NFE2L2 (0.47) | NFE2L2NAMPTMETGLO1SLC40A1 | |
| SCHEMBL476372 | 0.77 | MMP2 (0.37) | NFE2L2NAMPTGLO1SLC40A1 | |
| SCHEMBL476443 | 0.76 | CA1 (0.45) | NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2190822-A2 | 5-MEMBERED HETEROCYCLIC COMPOUNDS AS PROTON PUMP INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2010-06-02 | — | — | EP | disclosed |
| WO-2009041705-A9 | 5-MEMBERED HETEROCYCLIC COMPOUNDS AS PROTON PUMP INHIBITORS | TAKEDA PHARMACEUTICAL (JP) | 2009-08-13 | — | — | WO | disclosed |
| WO-2009041705-A2 | 5-MEMBERED HETEROCYCLIC COMPOUNDS AS PROTON PUMP INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-04-02 | — | — | WO | disclosed |