Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ6 | P48051 | 3/20 | 0.39 |
| ▸ | KCNJ5 | P48544 | 3/20 | 0.39 |
| ▸ | KCNJ3 | P48549 | 3/20 | 0.39 |
| ▸ | ACKR3 | P25106 | 6/20 | 0.37 |
| ▸ | MET | P08581 | 3/20 | 0.37 |
| ▸ | CCR3 | P51677 | 1/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1178248 | 0.88 | KCNJ6 (0.39) | KCNJ6KCNJ5KCNJ3ACKR3MET | |
| SCHEMBL1178051 | 0.88 | KCNJ6 (0.40) | KCNJ6KCNJ5KCNJ3MET | |
| SCHEMBL3699959 | 0.88 | KCNJ6 (0.42) | KCNJ6KCNJ5KCNJ3MET | |
| SCHEMBL7601286 | 0.86 | KCNJ6 (0.39) | KCNJ6KCNJ5KCNJ3ACKR3MET | |
| SCHEMBL7601160 | 0.86 | KCNJ6 (0.38) | KCNJ6KCNJ5KCNJ3ACKR3MET | |
| Bicarbonate SCHEMBL3692775 | 0.85 | PTGES (0.45) | ACKR3CCR3KLKB1 | |
| SCHEMBL1178386 | 0.85 | MET (0.41) | KCNJ6KCNJ5KCNJ3ACKR3MET | |
| SCHEMBL1178284 | 0.82 | MET (0.38) | KCNJ6KCNJ5KCNJ3ACKR3MET | |
| Bicarbonate SCHEMBL16735564 | 0.82 | ACKR3 (0.47) | ACKR3CCR3 | |
| Bicarbonate SCHEMBL9900300 | 0.82 | ALDH1A1 (0.43) | KCNJ6KCNJ5KCNJ3ACKR3CCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2268625-B1 | OXO-HETEROCYCLIC SUBSTITUTED CARBOXYLIC ACID DERIVATES AND THE USE THEREOF | Bayer Pharma AG (DE) | 2012-05-16 | — | — | EP | disclosed |