Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 3/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 3/20 | 0.36 |
| ▸ | CTSL | P07711 | 2/20 | 0.33 |
| ▸ | CTSB | P07858 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10565579 | 0.79 | AKT1 (0.49) | CTSSCTSKAKT1CTSLCTSB | |
| SCHEMBL28420950 | 0.78 | MIF (0.46) | CTSSCTSKAKT1CTSLCTSB | |
| SCHEMBL21422867 | 0.77 | PAX8 (0.44) | CTSSCTSKNPC1RAB9ACHRM2 | |
| SCHEMBL437284 | 0.76 | CHRNB2 (0.34) | CTSSCTSKNPC1RAB9ACHRM2 | |
| SCHEMBL12046629 | 0.76 | ALOX5 (0.36) | CTSSCTSKNPC1RAB9AMAPT | |
| SCHEMBL4865232 | 0.75 | MAPT (0.47) | CTSSCTSKAKT1CTSLNPC1 | |
| SCHEMBL1780463 | 0.75 | MAPT (0.43) | CTSSCTSKAKT1NPC1RAB9A | |
| SCHEMBL1781292 | 0.74 | NPC1 (0.46) | CTSSCTSKAKT1CTSLCTSB | |
| SCHEMBL10565261 | 0.74 | NOX1 (0.46) | CTSSCTSKAKT1CTSLCTSB | |
| SCHEMBL839023 | 0.74 | AKT1 (0.34) | CTSSAKT1CTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130216552-A1 | CRTH2 MODULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2013-08-22 | — | — | US | disclosed |
| WO-2012009137-A1 | CRTH2 MODULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2012-01-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130216552-A1 | CRTH2 MODULATORS | HRH2, HRH1, NR1H2 | CTSS 3640/4885CTSK 3063/4885AKT1 2726/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.