Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | HPGD | P15428 | 5/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 8/20 | 0.42 |
| ▸ | RAB9A | P51151 | 8/20 | 0.42 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | PKM | P14618 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.42 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.40 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.38 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11668799 | 0.73 | ASAH1 (0.42) | ALDH1A1HPGDTP53NPC1RAB9A | |
| SCHEMBL3696444 | 0.69 | ALDH1A1 (0.43) | ALDH1A1HPGDTP53NPC1RAB9A | |
| SCHEMBL7946803 | 0.67 | AKR1C3 (0.42) | ALDH1A1HPGDTP53NPC1RAB9A | |
| SCHEMBL9360752 | 0.67 | NPC1 (0.46) | ALDH1A1HPGDTP53NPC1RAB9A | |
| SCHEMBL1682736 | 0.66 | TET2 (0.41) | ALDH1A1HPGDMAPTHSD17B10KDM4E | |
| SCHEMBL170196 | 0.66 | RAB9A (0.64) | ALDH1A1HPGDTP53NPC1RAB9A | |
| SCHEMBL29374931 | 0.66 | RAB9A (0.64) | ALDH1A1HPGDTP53NPC1RAB9A | |
| SCHEMBL29580854 | 0.64 | RAB9A (0.59) | ALDH1A1HPGDTP53NPC1RAB9A | |
| SCHEMBL8783647 | 0.64 | RAB9A (0.59) | ALDH1A1HPGDTP53NPC1RAB9A | |
| SCHEMBL28598013 | 0.64 | ALDH1A1 (0.50) | ALDH1A1HPGDTP53NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010036977-A2 | COMBINATION THERAPIES WITH TOPIRAMATE FOR SEIZURES, RESTLESS LEGS SYNDROME, AND OTHER NEUROLOGICAL CONDITIONS | NEW ENGLAND MEDICAL CENTER HOSPITALS, INC. (US) | 2010-04-01 | — | — | WO | disclosed |
| US-RE39300-E1 | Inhibiting the development of tolerance to and/or dependence on an addictive substance | VIRGINIA COMMONWEALTH UNIVERSITY MEDICAL COLLEGE OF VIRGINIA (US) | 2006-09-19 | — | — | US | disclosed |
| EP-0938305-B1 | METHOD OF ALLEVIATING PAIN BY MEANS OF COMBINING TRAMADOL WITH AN NMDA ANTAGONIST | ALGOS PHARM CORP (US) | 2005-08-17 | — | — | EP | disclosed |
| EP-0942752-B1 | ANTICONVULSANT CONTAINING COMPOSITION FOR TREATING NEUROPATHIC PAIN | ALGOS PHARM CORP (US) | 2005-04-20 | — | — | EP | disclosed |
| EP-0778770-B1 | COMPOSITION ALLEVIATING PAIN, CONTAINING A NON-NARCOTIC ANALGESIC AND AN ANALGESIA ENHANCER | UNIV VIRGINIA COMMONWEALTH (US) | 2003-12-10 | — | — | EP | disclosed |
| US-6406716-B2 | Anticonvulsant containing composition for treating neuropathic pain | ENDO PHARMACEUTICALS INC. | 2002-06-18 | — | — | US | disclosed |
| EP-1146905-A1 | COX-2 INHIBITORS IN COMBINATION WITH NMDA-BLOCKERS FOR TREATING PAIN | Algos Pharmaceutical Corporation (US) | 2001-10-24 | — | — | EP | disclosed |
| US-20010008889-A1 | Anticonvulsant containing composition for treating neuropathic pain | ENDO PHARMACEUTICALS INC. | 2001-07-19 | — | — | US | disclosed |
| US-6187338-B1 | Anticonvulsant containing composition for treating neuropathic pain | ALGOS PHARMACEUTICAL CORPORATION | 2001-02-13 | — | — | US | disclosed |
| WO-2000029023-A1 | COX-2 INHIBITORS IN COMBINATION WITH NMDA-BLOCKERS FOR TREATING PAIN | ALGOS PHARMACEUTICAL CORPORATION (US) | 2000-05-25 | — | — | WO | disclosed |
| US-5834479-A | ADMINISTERING NONSTEROIDAL ANTIINFLAMMATORY DRUG ALONG WITH ANALGESIA ENHANCER WHICH IS AN N-METHYL-D-ASPARTATE RECEPTOR BLOCKER | JPMORGAN CHASE BANK | 1998-11-10 | — | — | US | disclosed |
| WO-1998007447-A1 | ANTICONVULSANT CONTAINING COMPOSITION FOR TREATING NEUROPATHIC PAIN | ALGOS PHARMACEUTICAL CORPORATION (US) | 1998-02-26 | — | — | WO | disclosed |
| US-5654281-A | Inhibiting the development of tolerance to and/or dependence on an addictive substance | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1997-08-05 | — | — | US | disclosed |
| EP-0778770-A1 | COMPOSITION ALLEVIATING PAIN, CONTAINING A NON-NARCOTIC ANALGESIC AND AN ANALGESIA ENHANCER | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1997-06-18 | — | — | EP | disclosed |
| US-5556838-A | BLOCKING N-METHYLASPARTATE RECEPTORS TO PREVENT ADDICTION | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1996-09-17 | — | — | US | disclosed |
| US-5502058-A | Method for the treatment of pain | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1996-03-26 | — | — | US | disclosed |
| WO-1996007412-A1 | COMPOSITION ALLEVIATING PAIN, CONTAINING A NON-NARCOTIC ANALGESIC AND AN ANALGESIA ENHANCER | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1996-03-14 | — | — | WO | disclosed |
| EP-0615749-A2 | Use of NMDA antagonists for the treatment of pain | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1994-09-21 | — | — | EP | disclosed |
| EP-0608893-A1 | Inhibiting the development of tolerance to and/or dependence on an additive substance | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1994-08-03 | — | — | EP | disclosed |
| US-5321012-A | Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance | VIRGINIA COMMONWEALTH UNIVERSITY MEDICAL COLLEGE (US) | 1994-06-14 | — | — | US | disclosed |