Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RNASE1 | P07998 | 1/20 | 0.36 |
| ▸ | TYMP | P19971 | 1/20 | 0.35 |
| ▸ | TK2 | O00142 | 5/20 | 0.33 |
| ▸ | TK1 | P04183 | 5/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6421057 | 0.92 | RNASE1 (0.34) | RNASE1TYMPTK2TK1HPGD | |
| SCHEMBL5668670 | 0.84 | RNASE1 (0.37) | RNASE1TYMPTK2TK1HPGD | |
| SCHEMBL4952762 | 0.83 | TK2 (0.39) | RNASE1TYMPTK2TK1HPGD | |
| SCHEMBL4949400 | 0.77 | TK2 (0.36) | RNASE1TYMPTK2TK1 | |
| SCHEMBL4470358 | 0.76 | TK2 (0.34) | RNASE1TYMPTK2TK1HPGD | |
| SCHEMBL7639912 | 0.76 | TK1 (0.34) | RNASE1TK2TK1HPGD | |
| SCHEMBL9396549 | 0.75 | RNASE1 (0.39) | RNASE1TK2TK1 | |
| SCHEMBL6223881 | 0.75 | TK2 (0.33) | RNASE1TYMPTK2TK1 | |
| SCHEMBL7195757 | 0.74 | TK1 (0.33) | TK2TK1 | |
| SCHEMBL261290 | 0.73 | TK1 (0.33) | RNASE1TK2TK1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7723508-B2 | a single-stranded antisense oligonucleotide, targeted to nucleic acid encoding lipid-free protein constituents of plasma lipoproteins, used for diagnosis and therapy of cardiovascular disorders, including myocardial infarction and atherosclerosis | ISIS PHARMACEUTICALS, INC. (US) | 2010-05-25 | — | — | US | disclosed |
| US-20060281698-A1 | a single-stranded antisense oligonucleotide, targeted to nucleic acid encoding lipid-free protein constituents of plasma lipoproteins, used for diagnosis and therapy of cardiovascular disorders, including myocardial infarction and atherosclerosis | IONIS PHARMACEUTICALS, INC. | 2006-12-14 | — | — | US | disclosed |
| EP-1442046-A4 | MAMMALIAN C-TYPE LECTINS | IMMUNEX CORP (US) | 2005-08-31 | — | — | EP | disclosed |
| EP-1442046-A2 | MAMMALIAN C-TYPE LECTINS | Immunex CorporatioN (US) | 2004-08-04 | — | — | EP | disclosed |
| WO-2003031578-A2 | MAMMALIAN C-TYPE LECTINS | IMMUNEX CORPORATION (US) | 2003-04-17 | — | — | WO | disclosed |