SCHEMBL6421057

SCHEMBL6421057

Cc1cn([C@]2([SiH](c3ccccc3)c3ccccc3)O[C@H](CO)[C@@H](O)[C@]2(OCCON(C)C)C(C)(C)C)c(=O)[nH]c1=O

nearest known ligand 0.37

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
RNASE1 P07998 1/20 0.34
TK1 P04183 8/20 0.33
TYMP P19971 1/20 0.32
TK2 O00142 4/20 0.31
HPGD P15428 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3696551 0.92 RNASE1 (0.36) RNASE1TK1TYMPTK2HPGD
SCHEMBL4470358 0.84 TK2 (0.34) RNASE1TK1TYMPTK2HPGD
SCHEMBL5668670 0.83 RNASE1 (0.37) RNASE1TK1TYMPTK2HPGD
SCHEMBL6223881 0.79 TK2 (0.33) RNASE1TK1TYMPTK2
SCHEMBL3516066 0.77 TK2 (0.32) TK1TK2HPGD
SCHEMBL4952762 0.76 TK2 (0.39) RNASE1TK1TYMPTK2HPGD
SCHEMBL4949400 0.74 TK2 (0.36) RNASE1TK1TYMPTK2
SCHEMBL7195757 0.74 TK1 (0.33) TK1TK2
SCHEMBL313036 0.73 TK1 (0.32) TK1TK2HPGD
SCHEMBL9396549 0.73 RNASE1 (0.39) RNASE1TK1TK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1578927-A2 ANTISENSE MODULATION OF NAV1.3 EXPRESSION Pharmacia Corporation (US) 2005-09-28 EP disclosed
EP-1575498-A2 ANTISENSE MODULATION OF MICROSOMAL PROSTAGLANDIN E2 SYNTHASE EXPRESSION Pharmacia Corporation (US) 2005-09-21 EP disclosed
EP-1572713-A2 ANTISENSE MODULATION OF ACYL-COA SYNTHETASE 1 EXPRESSION Pharmacia Corporation (US) 2005-09-14 EP disclosed
EP-1567538-A2 ANTISENSE MODULATION OF GFAT EXPRESSION Pharmacia Corporation (US) 2005-08-31 EP disclosed
EP-1556509-A2 ANTISENSE MODULATION OF VEGF CO-REGULATED CHEMOKINE-1 EXPRESSION Pharmacia Corporation (US) 2005-07-27 EP disclosed
EP-1549387-A1 ANTISENSE MODULATION OF FARNESOID X RECEPTOR EXPRESSION Pharmacia Corporation (US) 2005-07-06 EP disclosed
EP-1543159-A2 ANTISENSE MODULATION OF ENDOTHELIAL SPECIFIC MOLECULE 1 EXPRESSION Pharmacia Corporation (US) 2005-06-22 EP disclosed
EP-1539689-A2 ANTISENSE MODULATION OF ENDOTHELIAL LIPASE EXPRESSION Pharmacia Corporation (US) 2005-06-15 EP disclosed
EP-1534728-A2 ANTISENSE MODULATION OF GLUCOCORTICOID RECEPTOR EXPRESSION Pharmacia Corporation (US) 2005-06-01 EP disclosed
EP-1520021-A2 ANTISENSE MODULATION OF LRH1 EXPRESSION Pharmacia Corporation (US) 2005-04-06 EP disclosed
WO-2004030750-A1 ANTISENSE MODULATION OF FARNESOID X RECEPTOR EXPRESSION PHARMACIA CORPORATION (US) 2004-04-15 WO disclosed
WO-2004028458-A2 ANTISENSE MODULATION OF MICROSOMAL PROSTAGLANDIN E2 SYNTHASE EXPRESSION PHARMACIA CORPORATION (US) 2004-04-08 WO disclosed
WO-2004021978-A2 ANTISENSE MODULATION OF ENDOTHELIAL SPECIFIC MOLECULE 1 EXPRESSION PHARMACIA CORPORATION (US) 2004-03-18 WO disclosed
WO-2004016749-A2 ANTISENSE MODULATION OF ACYL-COA SYNTHETASE 1 EXPRESSION PHARMACIA CORPORATION (US) 2004-02-26 WO disclosed
WO-2004016754-A2 ANTISENSE MODULATION OF Nav1.3 EXPRESSION PHARMACIA CORPORATION (US) 2004-02-26 WO disclosed
WO-2004016224-A2 ANTISENSE MODULATION OF VEGF CO-REGULATED CHEMOKINE-1 EXPRESSION PHARMACIA CORPORATION (US) 2004-02-26 WO disclosed
WO-2004009541-A2 ANTISENSE MODULATION OF ENDOTHELIAL LIPASE EXPRESSION PHARMACIA CORPORATION (US) 2004-01-29 WO disclosed
WO-2004003201-A2 ANTISENSE MODULATION OF LRH1 EXPRESSION PHARMACIA CORPORATION (US) 2004-01-08 WO disclosed
WO-2003099215-A2 ANTISENSE MODULATION OF GLUCOCORTICOID RECEPTOR EXPRESSION PHARMACIA CORPORATION (US) 2003-12-04 WO disclosed
US-20030176374-A1 Oligonucleotide compositions and methods for the modulation of the expression of B7 protein ISIS PHARMACEUTICALS, INC. 2003-09-18 US disclosed